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| 4-Methylpyridin-2-amine Basic information |
| 4-Methylpyridin-2-amine Chemical Properties |
| Melting point | 96-99 °C (lit.) | | Boiling point | 230 °C (lit.) | | density | 1.0275 (estimate) | | vapor pressure | 3.71Pa at 25℃ | | refractive index | 1.5560 (estimate) | | Fp | 118 °C | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | DMF: freely soluble | | form | Flakes | | pka | pK1: 7.48(+1) (25°C) | | color | Slightly yellow to beige or brown | | Water Solubility | SOLUBLE | | Sensitive | Hygroscopic | | Merck | 14,466 | | BRN | 107066 | | LogP | 0.56-1.08 | | CAS DataBase Reference | 695-34-1(CAS DataBase Reference) | | NIST Chemistry Reference | 2-Pyridinamine, 4-methyl-(695-34-1) | | EPA Substance Registry System | 2-Pyridinamine, 4-methyl- (695-34-1) |
| 4-Methylpyridin-2-amine Usage And Synthesis |
| Chemical Properties | Light yellow to brown flakes | | Uses | Intermediate, medicine. | | Uses | 2-Amino-4-methylpyridine has been used in the synthesis of 2-amino-4-methyl-pyridinium 2-hy-droxy-benzoate. It is potent inhibitor of NOS2 (iNOS) in vitro. It is used as pharmaceutical intermediate. | | Synthesis Reference(s) | The Journal of Organic Chemistry, 72, p. 4554, 2007 DOI: 10.1021/jo070189y | | General Description | 2-Amino-4-methylpyridine acts as ligand and forms methoxo-bridged copper(II) complexes. | | Biochem/physiol Actions | 2-Amino-4-methylpyridine inhibits the activity of inducible NO synthase isolated from mouse RAW 264.7 cells in vitro. | | Purification Methods | Crystallise it from EtOH or a 2:1 *benzene/acetone mixture, and dry it under vacuum as in the prevous entry. [Beilstein 22/9 V 325.] |
| 4-Methylpyridin-2-amine Preparation Products And Raw materials |
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