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| 2-Fluoroadenine Basic information |
| 2-Fluoroadenine Chemical Properties |
| Melting point | >350 °C(lit.) | | Boiling point | 239.6±50.0 °C(Predicted) | | density | 2.05±0.1 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | DMSO (Sparingly, Sonicated, Heated), Methanol (Slightly, Heated) | | form | Solid | | pka | 6.84±0.20(Predicted) | | color | White to Light Yellow | | CAS DataBase Reference | 700-49-2(CAS DataBase Reference) |
| Hazard Codes | Xi,Xn | | Risk Statements | 36/37/38-22 | | Safety Statements | 26-36 | | WGK Germany | 3 | | RTECS | AU6264700 | | Hazard Note | Irritant | | HazardClass | IRRITANT, IRRITANT-HARMFUL | | HS Code | 29335990 |
| 2-Fluoroadenine Usage And Synthesis |
| Description | 2-Fluoroadenine is a purine nucleoside analog which has been investigated for suicide gene therapy for human malignancy. It has been used in the synthesis of heat shock protein 90 (Hsp90) inhibitors that have anticancer activity in vitro. It is also cytotoxic to CEM human leukemia cells with an IC50 value of 0.15 μM. | | Chemical Properties | white to light yellow crystal powder | | Uses | A purine nucleoside phosphorylase gene therapy for human malignancy. | | Uses | 2-Fluoroadenine is a fluorinated heterocyclic 2-ring compound. It is the base moiety for many carbocyclic and acyclic nucleoside analogues, which may be used in antineoplastic studies. 2-Fluoroadenine has been used as an intermediate for antineoplastic drugs such as fludarabine. fludarabine is a chemotherapy drug used in the treatment of chronic lymphocytic leukemia. | | Definition | ChEBI: 2-fluoroadenine is an organofluorine compound that is adenine in which the hydrogen at position 2 (the carbon between the two nitrogens of the pyrimidine ring) is replaced by a fluorine. It has a role as an antineoplastic agent. It is an organofluorine compound and a member of purines. |
| 2-Fluoroadenine Preparation Products And Raw materials |
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