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| 2-Amino-3-o-chlorobenzoyl-5-ethylthiophene Chemical Properties |
| Boiling point | 454.8±45.0 °C(Predicted) | | density | 1.302 | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | pka | -1.81±0.10(Predicted) |
| 2-Amino-3-o-chlorobenzoyl-5-ethylthiophene Usage And Synthesis |
| Description | 2-Amino-3-o-chlorobenzoyl-5-ethylthiophene can be used as the raw material for the synthesis of Etizolam, which is an important sedative hypnotic and antidepressant drug. Its derivative, 2-amino-3-(p-chlorobenzoyl) thiophene scaffold has been widely employed as a pharmacophore for the identification of small molecules acting as allosteric modulators at the adenosine A1 receptor.
| | References | Kai, Yong Mao, et al. "An Improved Synthesis of Etizolam." Journal of Southwest University of Science & Technology (2014).
Romagnoli, R, et al. Synthesis and biological evaluation of a new series of 2-amino-3-aroyl thiophene derivatives as agonist allosteric modulators of the A1 adenosine receptor. A position-dependent effect study..Longing for the end. Macmillan, 2015:185–204.
| | Chemical Properties | Yellow Solid | | Uses | Used in the preparation of thienylamide derivatives as cholecystokinin inhibitors. |
| 2-Amino-3-o-chlorobenzoyl-5-ethylthiophene Preparation Products And Raw materials |
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