Other grades of this product :
| 8-Bromotheophylline Basic information |
| 8-Bromotheophylline Chemical Properties |
| Melting point | 295-297°C | | Boiling point | 469.5±55.0 °C(Predicted) | | density | 1.862±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | DMSO (Slightly), Methanol (Slightly, Heated) | | pka | pKa 5.45±0.1(H2O t=24) (Uncertain) | | form | Solid | | color | White to Off-White | | BRN | 203069 | | CAS DataBase Reference | 10381-75-6 | | EPA Substance Registry System | 1H-Purine-2,6-dione, 8-bromo-3,7-dihydro-1,3-dimethyl- (10381-75-6) |
| Risk Statements | 20/21/22 | | Safety Statements | 24/25-36/37 | | RIDADR | 2811 | | HazardClass | 6.1(b) | | PackingGroup | III | | HS Code | 29395900 |
| 8-Bromotheophylline Usage And Synthesis |
| Description | Bromotheophylline is the active moiety of pamabrom, a mixture of 2-amino-2-methyl-propanol and bromotheophylline. From this mixture, bromotheophylline acts as a weak diuretic that has been used along with some analgesics to relieve the symptoms of premenstrual syndrome. Bromotheophylline is categorized on the FDA as a drug substance with an inactive state since March, 1980. It is also approved by Health Canada to be used alone or in combination with [DB00316] in OTC products. | | Chemical Properties | White Crystalline Powder | | Uses | The active component in the diuretic Diurex. | | Purification Methods | It is purified by dissolving in the minimum volume of dilute NaOH (charcoal), filtering and acidifying to pH ca 3.5-4. The solid that separates is collected, dried in vacuo at 100o and stored in a dark container. It has also been recrystallised from EtOH or AcOH. [Blitz & Beck J Prakt Chem [2] 118 158 1928, Fischer & Ach Chem Ber 28 3142 1895, Beilstein 26 H 476, 26 II 227, 26 III/IV 2447.] |
| 8-Bromotheophylline Preparation Products And Raw materials |
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