LICOCHALCONE-A

CAS No.：58749-22-7

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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LICOCHALCONE-A Basic information

Product Name:	LICOCHALCONE-A
Synonyms:	LICOCHALCONE-A;(E)-3-[5-(1,1-DIMETHYL-2-PROPENYL)-4-HYDROXY-2-METHOXYPHENYL]-1-(4-HYDROXYPHENYL)-2-PROPEN-1-ONE;4′,4-Dihydroxy-3-α,α-dimethylallyl-6-methoxychalcone;2-Propen-1-one, 3-[5-(1,1-dimethyl-2-propen-1-yl)-4-hydroxy-2-methoxyphenyl]-1-(4-hydroxyphenyl)-, (2E)-;(2E)-3-[4-Hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one;7-Dimethoxycoumarin;Licochalcone A, >=98%;Soluble LICOCHALCONE A, Liposomal LICOCHALCONE A, LICOCHALCONE A NanoEmulsion, NanoActive LICOCHALCONE A
CAS:	58749-22-7
MF:	C21H22O4
MW:	338.4
EINECS:	635-678-2
Product Categories:	The group of Liquorice;sy;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
Mol File:	58749-22-7.mol

LICOCHALCONE-A Chemical Properties

Melting point	100°
Boiling point	532.6±50.0 °C(Predicted)
density	1.171±0.06 g/cm3(Predicted)
storage temp.	-20°C
pka	7.82±0.15(Predicted)
form	Yellow solid
BRN	4534154
InChIKey	KAZSKMJFUPEHHW-DHZHZOJOSA-N

Safety Information

Hazard Codes	Xn
Risk Statements	20/21/22
Safety Statements	36/37
WGK Germany	3
RTECS	UB8755000

MSDS Information

LICOCHALCONE-A Usage And Synthesis

Uses	Licochalcone A is an estrogenic flavonoid that induces apoptosis in multiple types of cancer cells. Licochalcone A applied to bone marrow mesenchymal stem cells (BMSC)-aggregate has strong osteogenetic differentiation thus providing a promising strategy in treating osteoporotic weight-bearing bone fractures with defects.
General Description	An estrogenic flavanoid with anti-tumor and anti-parasitic properties. Shown to reduce Bcl-2 protein expression and induce apoptosis in several human cancer cell lines. Also induces cell differentiation and enhances the effect of paclitaxel and vinblastine chemotherapy. Reported to interfere with parasite mitochondrial electron transport chain and energy metabolism.
Biochem/physiol Actions	Inhibits vegetative growth of spore-forming bacteria, B. subtilis and other food-contaminating microorganisms.

LICOCHALCONE-A Preparation Products And Raw materials

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