4-Hydroxypiperidine

CAS No.：5382-16-1

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

View the full Disclaimer

Other grades of this product :

4-Hydroxypiperidine Basic information

Product Name:	4-Hydroxypiperidine
Synonyms:	PIPERIDIN-4-OL;4-PIPERIDINOL;4PPOL;4-HYDROXYPIPERIDINE;HYDROXYPIPERIDINE(4-);AURORA KA-1006;4-Hydroxypiperidine base;4-Hydroxypiperidine, 99+%
CAS:	5382-16-1
MF:	C5H11NO
MW:	101.15
EINECS:	226-373-1
Product Categories:	Building Blocks;C5 to C7;Piperidines, Piperidones, Piperazines;Chemical Synthesis;Heterocyclic Building Blocks;Piperidines;Alcohols and Derivatives;Amines and Anilines;Pyrans, Piperidines &Piperazines;Piperidine;Heterocyclic Compounds;NADIFLOXACIN;Pyrans, Piperidines & Piperazines
Mol File:	5382-16-1.mol

4-Hydroxypiperidine Chemical Properties

Melting point	86-90 °C
Boiling point	108-114 °C/10 mmHg (lit.)
density	0.9903 (rough estimate)
vapor pressure	13Pa at 25℃
refractive index	1.4400 (estimate)
Fp	226 °F
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Solid
pka	14.94±0.20(Predicted)
color	Off-White to pale Yellow
PH	11.5-11.7 (H2O)Aqueous solution
Water Solubility	soluble
Sensitive	Hygroscopic
BRN	102738
InChIKey	HDOWRFHMPULYOA-UHFFFAOYSA-N
LogP	-0.35 at 25℃
CAS DataBase Reference	5382-16-1(CAS DataBase Reference)
NIST Chemistry Reference	4-Hydroxypiperidine(5382-16-1)

Safety Information

Hazard Codes	Xi,C
Risk Statements	36/37/38-34
Safety Statements	26-36-37/39-45-36/37/39-27
RIDADR	3263
WGK Germany	3
Hazard Note	Irritant
HazardClass	8
PackingGroup	III
HS Code	29333999

MSDS Information

Provider	Language
4-Hydroxypiperidine	English
SigmaAldrich	English
ACROS	English
ALFA	English

4-Hydroxypiperidine Usage And Synthesis

Chemical Properties	yellow to yellow-orange wet solid
Uses	4-Hydroxypiperidine is used as a reagent for the synthesis of acridine (A190900) derivatives and fibrinogen receptor antagonists.
Uses	4-Hydroxypiperidine (4-Piperidinol) can be used in the synthesis of a highly potent and selective IP (PGI(2) receptor) agonist. It can also be used in the study of copper-catalyzed N- versus O-arylation.
General Description	The molecular structure, vibrational spectra, NBO and UV-spectral analysis of 4-Hydroxypiperidine have been studied. The compounds with a substituted 4-piperidinol core have been found to be potent antagonists of the human H(3) receptor.
Flammability and Explosibility	Notclassified

4-Hydroxypiperidine Preparation Products And Raw materials

Preparation Products

2-(4-Hydroxypiperidin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxamide-->1-(5-(Hydroxymethyl)pyrimidin-2-yl)piperidin-4-ol-->1-(4-(Hydroxymethyl)-6-(trifluoromethyl)pyrimidin-2-yl)piperidin-4-ol-->Ethyl 2-(4-hydroxypiperidin-1-yl)pyrimidine-5-carboxylate-->2-(4-Hydroxypiperidin-1-yl)pyrimidine-5-carboxylic acid-->2-(4-Hydroxypiperidin-1-yl)pyrimidine-5-carboxamide-->Loperamide-->Ethyl 2-(4-hydroxypiperidin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylate-->4-Chloro-N-methylpiperidine-->1-(2-FLUORO-4-NITROPHENYL)PIPERIDIN-4-OL-->1-(5-aminopyridin-2-yl)piperidin-4-ol-->1-(Benzyloxycarbonyl)-4-piperidinone-->4-Bromopiperidine hydrobromide-->1-[5-NITROPYRIDIN-2-YL]PIPERIDINE-4-OL-->1-Boc-4-methanesulfonyloxypiperidine-->Ebastine-->1-Benzyl-4-hydroxypiperidine-->Methyl 4-hydroxypiperidine-1-carboxyl

Welcome！

Please leave a message for us or use the following ways to contact us, we will reply to you as soon as possible, and provide you with the most sincere service, thank you.

NO. 18 ,Wujiang Road, Wulidian Street, Jiangbei District, Chongqing
+86-23-6139-8061 +86-13650506873
danny@chemdad.com sales@chemdad.com
www.chemdad.com
WhatsApp +86-13650506873