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| Indole-4-carboxaldehyde Basic information |
| Indole-4-carboxaldehyde Chemical Properties |
| Melting point | 139-143 °C(lit.) | | Boiling point | 339.1±15.0 °C(Predicted) | | density | 1.278±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | pka | 15.84±0.30(Predicted) | | form | powder to crystal | | color | Light yellow to Brown | | Water Solubility | Soluble in ethanol and acetone. Insoluble in water. | | Sensitive | Air Sensitive | | CAS DataBase Reference | 1074-86-8(CAS DataBase Reference) | | NIST Chemistry Reference | 1H-indole-4-carboxaldehyde(1074-86-8) |
| Hazard Codes | Xn,Xi | | Risk Statements | 22-36-43 | | Safety Statements | 26-36/37 | | WGK Germany | 3 | | Hazard Note | Irritant/Keep Cold | | HazardClass | IRRITANT | | HS Code | 29333990 |
| Indole-4-carboxaldehyde Usage And Synthesis |
| Chemical Properties | White to dark brown solid | | Uses | Indole-4-carboxaldehyde is usually used as reactant in Biginelli reaction,preparation of antitumor agents,intramolecular Friedel-Crafts acylation,preparation of inhibitors of cell division in E. Coli,synthesis of Hantzsch pyridine-containing Schiff bases.
| | Uses | 4-Indolecarbaldehyde is a synthetic intermediate used for pharmaceutical synthesis. Also used as reactant in Biginelli reaction, synthesis of aurora kinase A inhibitors, preparation of antitumor agents, intermolecular Friedel-Crafts acylation, preparation of inhibitors of cell division in E. coli and synthesis of Hantzsch pyridine-containing Schiff bases. | | Synthesis Reference(s) | The Journal of Organic Chemistry, 46, p. 1752, 1981 DOI: 10.1021/jo00321a053Tetrahedron, 39, p. 3695, 1983 DOI: 10.1016/S0040-4020(01)88608-7 | | General Description | Indole-4-carboxaldehyde participates in the synthesis of arcyriacyanin A. Synthesis of 4-indole-4-carboxaldehyde has been reported. Intramolecular Friedel-Crafts (FC) acylation of indole-4-carboxaldehyde has been reported. |
| Indole-4-carboxaldehyde Preparation Products And Raw materials |
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