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| Pamoic acid disodium salt Basic information |
| Product Name: | Pamoic acid disodium salt | | Synonyms: | PAMOIC ACID DISODIUM SALT 98+%;DisodiumPamoate98%;DISODIUMEMBONATE;4,4μ-Methylenebis(3-hydroxy-2-naphthoic acid), Embonic acid, Sodium pamoate;2-Naphthalenecarboxylic acid, 4,4'-methylenebis[3-hydroxy-, disodium salt;Disodium 4-[(3-carboxylato-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylate;1,1'-Methylenebis(2-hydroxy-3-naphthalenecarboxylic acid sodium) salt;1,1'-Methylenebis(2-hydroxy-3-naphthalenecarboxylic acid)disodium salt | | CAS: | 6640-22-8 | | MF: | C23H14Na2O6 | | MW: | 432.33 | | EINECS: | 229-653-1 | | Product Categories: | | Mol File: | 6640-22-8.mol |
| Pamoic acid disodium salt Chemical Properties |
| Pamoic acid disodium salt Usage And Synthesis |
| Chemical Properties | pale yellow to yellow powder | | Uses | Pamoic acid disodium salt, a supposedly inactive component in many formulations of drugs used to modulate release, is a potent agonist of the orphan receptor GPR35. GPR35 is a class A, rhodopsin-like G protein-coupled receptor (GPCR), strongly expressed in the lower intestine and colon, dorsal root ganglia, as well as a variety of immune cells including monocytes and dendritic cells. Targeting GPR35 provides potential therapeutic opportunities in a range of conditions, such as inflammation, pain and cancer. | | Flammability and Explosibility | Notclassified | | Biological Activity | Pamoic acid disodium salt is a GPR35 agonist. Induces GPR35 internalization and activates ERK1/2 (EC50 values are 22 and 65 nM respectively). Mediates recruitment of β-arrestin2 to GPR35. Also exhibits antinociceptive effects in a mouse model of visceral pain. |
| Pamoic acid disodium salt Preparation Products And Raw materials |
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