D-Pyroglutamic acid

CAS No.：4042-36-8

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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D-Pyroglutamic acid Basic information

Product Name:	D-Pyroglutamic acid
Synonyms:	(R)-5-PYRROLIDONE-2-CARBOXYLIC ACID;(R)-(+)-5-OXO-2-PYRROLIDINECARBOXYLIC ACID;(R)-5-OXO-2-PYRROLIDINECARBOXYLIC ACID;(R)-5-OXOPYRROLIDINE-2-CARBOXYLIC ACID;(R)-(+)-2-PYRROLIDINONE-5-CARBOXYLIC ACID;(R)-2-PYRROLIDINONE-5-CARBOXYLIC ACID;(R)-(+)-2-PYRROLIDONE-5-CARBOXYLIC ACID;(R)-2-PYRROLIDONE-5-CARBOXYLIC ACID
CAS:	4042-36-8
MF:	C5H7NO3
MW:	129.11
EINECS:	223-735-0
Product Categories:	Amino Acids & Derivatives;Chiral Reagents;Pyroglutamic acid [Pyr, pGu];Amino Acids 13C, 2H, 15N;Amino Acids;amino acid;Amino Acids and Derivatives;Heterocycles;chiral;Biochemistry;Biological-modified Amino Acids;for Resolution of Bases;Optical Resolution;Synthetic Organic Chemistry;pharmacetical;bc0001
Mol File:	4042-36-8.mol

D-Pyroglutamic acid Chemical Properties

Melting point	155-162 °C
alpha	27.5 º (c=10,1N NaOH)
Boiling point	239.15°C (rough estimate)
density	1.3816 (rough estimate)
refractive index	10 ° (C=5, H2O)
storage temp.	Sealed in dry,Room Temperature
solubility	Dimethylformamide, DMSO (Slightly), Methanol (Slightly), Water
form	Solid
pka	3.48±0.20(Predicted)
color	Off-White to Light Beige
optical activity	[α]22/D +10°, c = 1.5 in H2O
Water Solubility	soluble
Merck	14,8001
BRN	82133
InChIKey	ODHCTXKNWHHXJC-GSVOUGTGSA-N
CAS DataBase Reference	4042-36-8(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36-37/39
WGK Germany	3
HS Code	29339900

MSDS Information

Provider	Language
ACROS	English
SigmaAldrich	English
ALFA	English

D-Pyroglutamic acid Usage And Synthesis

Chemical Properties	white to light yellow crystal powde
Uses	Serves as a building block in the synthesis of diphthamide
Uses	Serves as a building block in the synthesis of diphthamide.
Definition	ChEBI: The D-enantiomer of 5-oxoproline.
Purification Methods	Purify R-pyroglutamic acid by dissolving it in H2O, filtering, passing the filtrate through Dowex 50 (H+ form), washing with H2O, pooling washings, evaporating, removing H2O azeotropically with Me2CO and *C6H6, washing the residue with Et2O and recrystallising from EtOH/pet ether. [Pradeller et al. Collect Czech Chem Commun 42 79, 80 1977, Beilstein 22/6 V 7.]

D-Pyroglutamic acid Preparation Products And Raw materials

Raw materials	5-Hydroxymethylpyrrolidin-2-one-->L-Pyroglutamic acid-->D(-)-Glutamic acid-->(-)-D-PYROGLUTAMIC ACID METHYL ESTER
Preparation Products	L-Pyroglutamic acid-->Ethanol-->(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine-->FASORACETAM-->D-PYROGLUTAMIC ACID TERT-BUTYL ESTER

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