Product

3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

CAS No.：63234-80-0

Other grades of this product :

3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one Basic information

Product Name:	3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
Synonyms:	3-(2-Chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]-pyrididine-4-one (intermediate of Risperidone);3-(2-CHLOROETHYL)-2-METHYL-6,7,8,9-TETRAHYDRO-4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE;3-(2-CHLORO-ETHYL)-2-METHYL-6,7,8,9-TETRAHYDRO-PYRIDO[1,2-A]PYRIMIDIN-4-ONE;3-(2-CHLOROETHYL)-6,7,8,9-TETRAHYDRO-2-METHYL-4H-PYRIDINO[1,2-A]PYRIMIDINE-4-ONE;3-(2-CHLOROETHYL)-6,7,8,9-TETRAHYDRO-2-METHYL-4H-PYRIDO(1,2A)PYRIMIDINE-4-ONE;3-(2-CHLOROETHYL)-6,7,8,9-TETRAHYDRO-2-METHYL-4H-PYRLDO[1,2-A]PYRIMDIN-4-ONE;3-2(2-chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-alpha]pyrimnidin-4-one;3-2(2-CHLOROETHYL)-6,7,8,9-TETRAHYDRO-2-METHYL-4H-PYRIDO[1,2-A]PYRIMDIN-4-ONE
CAS:	63234-80-0
MF:	C11H15ClN2O
MW:	226.7
EINECS:	613-192-1
Product Categories:	Bases & Related Reagents;Intermediates & Fine Chemicals;Nucleotides and Nucleosides;Nucleotides;Pharmaceuticals;Intermediates;(intermediate of Risperidone)
Mol File:	63234-80-0.mol

3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one Chemical Properties

Melting point	68.5-69.5 °C
Boiling point	337 °C
density	1.30
Fp	157 °C
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Solid
pka	3.58±0.70(Predicted)
color	White to Off-White
InChIKey	CMWCQQUYLPYOMY-UHFFFAOYSA-N
CAS DataBase Reference	63234-80-0(CAS DataBase Reference)

Safety Information

Hazard Codes	T
Risk Statements	25
Safety Statements	45
HazardClass	IRRITANT

MSDS Information

3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one Usage And Synthesis

Chemical Properties	White Solid
Uses	An intermediate in the synthesis of Risperidone
Uses	3-(2-Chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one (Risperidone EP Impurity L) is an intermediate in the synthesis of Risperidone (R525000), which is a combined serotonin (5-HT2) and dopamine (D2) receptor antagonist.

3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one Preparation Products And Raw materials

Raw materials

Hydrochloric acid-->Ethyl acetate-->Dichloromethane-->PETROLEUM ETHER-->Toluene-->Phosphorus oxychloride-->Ammonium hydroxide-->Isopropyl alcohol-->Hydrogen-->Palladium hydroxide-->2-Aminopyridine-->2-Acetylbutyrolactone-->3-(2-Chloroethyl)-2-methylpyrido[1,2-a]pyrimidin-4-one

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