Other grades of this product :
| Ropivacaine hydrochloride Basic information |
| Product Name: | Ropivacaine hydrochloride | | Synonyms: | (S)-1-propyl-2',6'-dimethylanilinoformoxylpiperidine monohydrochloride monohydrate;(S)-1-propyl-2',6'-dimethylanilinoformoxylpiperidine,monohydrochloride,monohydrate;(S)-Ropivaxaine hydrochloride;(S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide hydrochloride;Ropivacaine hydrochloride;(2S)-N-(2,6-Dimethylphenyl)-1-propyl-2-piperidinecarboxamide Hydrochloride Hydrate;LEA-103;(S)-ropivacaine hydrochloride hydrate | | CAS: | 132112-35-7 | | MF: | C17H26N2O.ClH.H2O | | MW: | 328.88 | | EINECS: | 663-286-1 | | Product Categories: | Inhibitors;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;API | | Mol File: | 132112-35-7.mol |
| Ropivacaine hydrochloride Chemical Properties |
| Melting point | 267-269°C | | alpha | D20 -7.28° (c = 2 in water) | | storage temp. | 2-8°C | | solubility | H2O: soluble5mg/mL, clear | | form | powder | | color | white to off-white | | optical activity | [α]/D -9 to -12, c = 1 in methanol | | InChIKey | VSHFRHVKMYGBJL-CKUXDGONSA-N | | CAS DataBase Reference | 132112-35-7(CAS DataBase Reference) |
| Ropivacaine hydrochloride Usage And Synthesis |
| Description | (–)-Ropivacaine is a potent and reversible blocker of sodium channels in nerve fibers. In vivo, (–)-ropivacaine induces complete impairment of proprioception, motor function, and nociception in the hindleg of rats when 100 μL of an 8 mM solution is injected percutaneously into the sciatic nerve. (–)-Ropivacaine depresses myocardial contractile force in isolated rat hearts less potently than (±)-ropivacaine, as well as (–)- and (±)-bupivacaine . Formulations containing (–)-ropivacaine have been used as local anesthetics during surgery and childbirth. | | Chemical Properties | White Solid | | Uses | Anesthetic (local) | | Uses | Anesthetic (local). | | Uses | Ropivacaine hydrochloride monohydrate has been used as an analyte in tandem mass spectrometry and as an amide-based local anaesthetic to test its effect on breast cancer cell methylation. | | Definition | ChEBI: The monohydrate form of (S)-ropivacaine hydrochloride. | | General Description | Ropivacaine has lidocaine-related structure with tertiary amine side chains.?It is a pure S(-)enantiomer with a propyl group on the piperidine nitrogen atom. | | Biochem/physiol Actions | Local anaesthetic with less cardiotoxicity than bupivacaine; causes reversible blockade of impulse propagation along nerve fibres by preventing the inward movement of sodium ions through the cell membrane of the nerve fibers. |
| Ropivacaine hydrochloride Preparation Products And Raw materials |
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