Other grades of this product :
| Thianaphthene Basic information |
| Thianaphthene Chemical Properties |
| Melting point | 30-33 °C | | Boiling point | 221-222 °C(lit.) | | density | 1.149 g/mL at 25 °C(lit.) | | refractive index | 1.6332 (estimate) | | Fp | >230 °F | | storage temp. | Store below +30°C. | | solubility | 0.13g/l | | form | Crystalline Solid | | pka | 32.4 | | Specific Gravity | 1.149 | | color | White to pink or yellow | | Water Solubility | insoluble | | Merck | 14,9303 | | BRN | 80580 | | InChIKey | FCEHBMOGCRZNNI-UHFFFAOYSA-N | | CAS DataBase Reference | 95-15-8(CAS DataBase Reference) | | NIST Chemistry Reference | Benzo[b]thiophene(95-15-8) | | EPA Substance Registry System | Benzo[b]thiophene (95-15-8) |
| Thianaphthene Usage And Synthesis |
| Chemical Properties | WHITE TO RED CRYSTALLINE LOW MELTING SOLID | | Uses | Benzo[b]thiophene has application in organic as well as pharmaceutical industry as a component in the synthesis of Raloxifene, a breast cancer therapeutic, or hydrodesulfurization reactions. | | Uses | manufacture of pharmaceuticals, thioindigo. | | Uses | Benzo[b]thiophene is used in the preparation of 2-thianapthenylphenyllithium, via metalation by n-butyllithium. It is used in organic as well as pharmaceutical industry as a component in the synthesis of raloxifene, a breast cancer therapeutic, or hydrodesulfurization reactions. | | Uses | Thianaphthene may be used in the preparation of 2-thianapthenylphenyllithium, via metalation by n-butyllithium. | | Application | Thianaphthene may be used in the preparation of 2-thianapthenylphenyllithium, via metalation by n-butyllithium.Reaction of ethyl diazoacetate with thianaphthene has been reported. | | Synthesis Reference(s) | Journal of the American Chemical Society, 69, p. 2008, 1947 DOI: 10.1021/ja01200a053Tetrahedron, 27, p. 1253, 1971 DOI: 10.1016/S0040-4020(01)90874-9 | | General Description | Reaction of ethyl diazoacetate with thianaphthene has been reported. | | Purification Methods | 1-Benzothiophene has the odour of naphthalene. If the IR spectrum is not very good, then suspend it in a faintly alkaline aqueous solution and steam distil it. Extract the distillate with Et2O, dry the extract (CaCl2), filter, evaporate the solvent and fractionate the residue. The distillate sets solid. The sulfoxide has m 142o, the picrate has m 148-149o (yellow crystals from EtOH) and the styphnate has m 136-137o. [Hansch & Lindwall J Org Chem 10, 381 1945, Meyer & Meyer Chem Ber 52B 1249 1919, Weisgerber & Kruber 53 1551 1920, Iddon & Scrowston Adv Heterocycl Chem 11 177 1970, Beilstein 17/2 V 6.] |
| Thianaphthene Preparation Products And Raw materials |
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