Other grades of this product :
| Curcumol Basic information |
| Product Name: | Curcumol | | Synonyms: | 6H-3a,6-Epoxyazulen-6-ol, octahydro-3-methyl-8-methylene-5-(1-methylethyl)-, (3S,3aS,5S,6R,8aS)-;(3S,3aS,5S,6R,8aS)-Octahydro-3-methyl-8-methylene-5-(1-methylethyl)-6H-3a,6-epoxyazulen-6-ol;CURCUMOL;(3s-(3a,3aa,5a,6a,8ab))-octahydro-3-methyl-8-methylene-5-(1-methylethyl)-6h-3a,6-epoxyazulen-6-ol;5,8-Epoxy-10(14)-guaien-8-ol;(3S-(3alpha,3Aalpha,5alpha,6alpha,8abeta))-octahydro-3-methyl-8-methylene-5-(1-methylethyl)-6H-3A,6-epoxyazulen-6-ol;Curcumae;Curcumol USP/EP/BP | | CAS: | 4871-97-0 | | MF: | C15H24O2 | | MW: | 236.35 | | EINECS: | | Product Categories: | chemical reagent;Inhibitors;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Miscellaneous Natural Products | | Mol File: | 4871-97-0.mol |
| Curcumol Chemical Properties |
| Melting point | 141.0 to 145.0 °C | | Boiling point | 334.5±42.0 °C(Predicted) | | density | 1.06±0.1 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | pka | 13.02±0.60(Predicted) | | form | neat | | color | White to Light yellow | | InChIKey | QRMPRVXWPCLVNI-YYFQZIEXSA-N | | CAS DataBase Reference | 4871-97-0 |
| WGK Germany | 3 | | HS Code | 29321900 |
| Curcumol Usage And Synthesis |
| Biological Activity | Curcumol is a biologically active sesquiterpene with many pharmacological activities such as anticancer, antimicrobial, antifungal, antiviral and anti-inflammatory. It efficiently induces apoptosis in many cancer cells by targeting key signaling pathways such as MAPK/ERK, PI3K/Akt and NF-κB, which are often dysregulated in several cancers. | | in vitro | Curcumol ((-)-Curcumol) is the major component extracted from root of Rhizoma Curcumae . Curcumol exerts anticancer effect in cholangiocarcinoma cells via down-regulating CDKL3. It induces cell cycle arrest in colon cancer cells via reactive oxygen species and Akt/ GSK3β/cyclin D1 pathway. It suppresses breast cancer cell metastasis by inhibiting MMP-9 via JNK1/2 and Akt-dependent NF-κB signaling pathways. |
| Curcumol Preparation Products And Raw materials |
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