L-HOMOCYSTEINE

L-HOMOCYSTEINE
  • CAS No.:6027-13-0
Other grades of this product :
L-HOMOCYSTEINE Basic information
Product Name:L-HOMOCYSTEINE
Synonyms:(2S)-2-ammonio-4-mercaptobutanoate;BUTANOIC ACID, 2-AMINO-4-MERCAPTO-, (S)-;BUTYRIC ACID, 2-AMINO-4-MERCAPTO-, L-;L-HOMOCYSTEINE;(S)-HOMOCYSTEINE;(S)-2-AMINO-4-MERCAPTOBUTANOIC ACID;H-Hcys-OH;(S)-2-Amino-4-(methylmercapto)butanoic acid
CAS:6027-13-0
MF:C4H9NO2S
MW:135.18
EINECS:227-891-0
Product Categories:Amino Acids
Mol File:6027-13-0.mol
L-HOMOCYSTEINE Chemical Properties
Melting point 232°C
Boiling point 299.7±35.0 °C(Predicted)
density 1.149 (estimate)
refractive index 1.5480 (estimate)
storage temp. -20°C
solubility Aqueous Acid (Sparingly, Heated, Sonicated), Water (Slightly, Heated)
pka2.24±0.10(Predicted)
form solid
color White to Off-White
optical activity[α]/D 25.5±1.5°, c = 1 in 1 M HCl
Stability:Air Sensitive, Hygroscopic
InChIKeyFFFHZYDWPBMWHY-VKHMYHEASA-N
CAS DataBase Reference6027-13-0(CAS DataBase Reference)
Safety Information
Hazard Codes Xn
Risk Statements 22
Safety Statements 22-24/25
WGK Germany 3
HS Code 29309090
MSDS Information
L-HOMOCYSTEINE Usage And Synthesis
Chemical PropertiesColourless or nearly colourless solid
UsesL-Homocysteine is the hydrolysis product of adenosine (A280400), a purine nucleoside. Metabolic fate of L-Homocysteine is converted back to L-Methionine( M260440) via tetrahydrofolate.
UsesL-homocysteine has been used as a supplement in cell culture media.
DefinitionChEBI: Homocysteine with L configuration.
General DescriptionL-homocysteine is used to diagnose homocystinuria.
Biochem/physiol ActionsElevated homocysteine levels in plasma and tissue are associated with brain atrophy in Alzheimer′s disease as well as in healthy eldery subjects. Increased homocysteine is due to deficiencies in vitamin B status, specifically folate, B6 and B12 vitamins, which act as cofactors for enzymes involved in homocysteine metabolism.
Purification MethodsCrystallise L-homocysteine from aqueous EtOH. All operations should be carried out under N2 as the thiol readily oxidizes in air. The acid (3g) is dissolved in freshly boiled H2O (
L-HOMOCYSTEINE Preparation Products And Raw materials
Preparation ProductsSulfobetaine-->5'-DEOXY-S-ADENOSYL-L-HOMOCYSTEINE

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