5,6-Dimethoxyindole

5,6-Dimethoxyindole
  • CAS No.:14430-23-0

Important Notice

  1. This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
  2. This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
  3. The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.
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5,6-Dimethoxyindole Basic information
Product Name:5,6-Dimethoxyindole
Synonyms:5,6-Dimethoxyindole,99%;5,6-Dimethoxy-1H-indole 99%;5,6-Dimethoxy-1H-indole99%;AKOS JY2083477;5,6-DIMETHOXYINDOLE;5,6-DIMETHOXY-1H-INDOLE;1H-Indole, 5,6-dimethoxy-;5,6-Dimethoxyindole 99%
CAS:14430-23-0
MF:C10H11NO2
MW:177.2
EINECS:238-402-5
Product Categories:Amines;Aromatics;Heterocyclic Compounds;Indole Derivatives;Building Blocks;Heterocyclic Building Blocks;Indoles and derivatives;Indoline & Oxindole;Indoles
Mol File:14430-23-0.mol
5,6-Dimethoxyindole Chemical Properties
Melting point 154-157 °C (lit.)
Boiling point 198°C 8mm
density 1.182±0.06 g/cm3(Predicted)
Fp 198°C/8mm
storage temp. Sealed in dry,Room Temperature
pka16.93±0.30(Predicted)
form Powder
color Beige
Water Solubility Insoluble in water.
λmax306nm(EtOH)(lit.)
BRN 5683
InChIKeyQODBZRNBPUPLEZ-UHFFFAOYSA-N
CAS DataBase Reference14430-23-0(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Safety Statements 22-24/25
WGK Germany 3
F 10
HazardClass IRRITANT
HS Code 29339900
MSDS Information
ProviderLanguage
SigmaAldrich English
ALFA English
5,6-Dimethoxyindole Usage And Synthesis
Chemical PropertiesBeige powder
Uses5,6-Dimethoxyindole is an indole derivative as analgesic antiinflammatory. It was used in the synthesis of N-benzyl-N-cyclopropyl-5,6-dimethoxyindole-3-glyoxalamide.
Application5,6-Dimethoxyindole was used in the synthesis of N-benzyl-N-cyclopropyl-5,6-dimethoxyindole-3-glyoxalamide.Reactant in synthesis of indolylhydroxyoxindoles via enantioselective Friedel-Crafts reactionReactant in synthesis of benzyl trimethoxyindolesReactant for synthesis of benzoylpiperazinyl-indolyl ethane dione derivatives as HIV-1 inhibitorsReactant for synthesis of 1-aroylindole 3-aroylindoles combretastatin A-4 analogs as antitumor agents and tubulin polymerization inhibitorsReactant for preparation of tryptophanol derivatives via the Grignard reaction
Synthesis Reference(s)Journal of the American Chemical Society, 75, p. 5887, 1953 DOI: 10.1021/ja01119a030Synthesis of 5,6-Dimethoxyindoles and 5,6-Dimethoxyoxindoles. A New Synthesis of Indoles DOI: 10.1021/ja01619a049
5,6-Dimethoxyindole Preparation Products And Raw materials

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