Product

2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one

CAS No.：142217-81-0

Other grades of this product :

2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one Basic information

Product Name:	2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one
Synonyms:	Entecavir InterMediate VIII IsoMer;2-aMino-1,9-dihydro-9-[(1S,3R,4S)-2-Methylene-4-(benzyloxy)-3-[(benzyloxy)Methyl]cyclopentyl]-6H-Purin-6-one;Entecavir InterMediate N-1;[1S-(1α,3α,4β)]-2-AMino-1,9-dihydro-9-[2-Methylene-4-(phenylMethoxy)-3-[(phenylMethoxy)Methyl]cyclopentyl]-6H;2-AMino-1,9-dihydro-9-[(1S,3R,4S)-2-Methylene-4-(phenylMethoxy)-3-[(phenylMethoxy)Methyl]cyclopentyl]-6H-purin-6-one;Entecavir Impurity 4;Dibenzyl Entecavir;Dibenzyl Entecavir (3',5'-Di-O-Benzyl Entecavir)
CAS:	142217-81-0
MF:	C26H27N5O3
MW:	457.52
EINECS:	1312995-182-4
Product Categories:
Mol File:	142217-81-0.mol

2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one Chemical Properties

Melting point	245-247°C (dec.)
density	1.34
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	DMSO (Slightly)
form	Solid
pka	9?+-.0.20(Predicted)
color	White to Pale Beige
CAS DataBase Reference	142217-81-0(CAS DataBase Reference)

Safety Information

HS Code

29335990

MSDS Information

2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one Usage And Synthesis

Chemical Properties	White powder
Uses	3’5’Di-O-benzyl Entecavir is an intermediate in the preparation of the hepatitis B antiviral agent, Entecavir (E558900).
Uses	3’,5’-Di-O-benzyl Entecavir is an intermediate in the preparation of the hepatitis B antiviral agent, Entecavir (E558900).

2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one Preparation Products And Raw materials

Raw materials

Benzene, [(2,4-cyclopentadien-1-ylmethoxy)methyl]--->(2R,3S,5S)-3-(Benzyloxy)-5-[2-[[(4-methoxyphenyl)diphenylmethyl]amino]-6-(benzyloxy)-9H-purin-9-yl]-2-(benzyloxymethyl)cyclopentanone-->(1S,2R,3S,5R)-2-(Benzyloxymethyl)-6-oxabicyclo[3.1.0]hexan-3-ol-->SODIUM CYCLOPENTADIENIDE-->(1S,2R,3S,5R)-3-(Phenymethyloxy)-2-(phenylmethoxy)methyl-6-oxabicyclo[3.1.0]hexane-->6-(Benzyloxy)-9-((1S,3R,3S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl)-N-((4-methoxyphenyl)diphenylmethyl)-9H-purin-2-amine-->(1S, 2R)-2-(Benzyloxymethyl)-1-hydroxy-3-cyclopentene-->(2R,3S,5S)-3-(Benzyloxy)-5-[2-[[(4-methoxyphenyl)diphenylmethyl]amino]-6-(phenylmethoxy)-9H-purin-9-yl]-2-(benzyloxymethyl)cyclopentanol-->(1S,2S,3S,5S)-5-(2-Amino-6-(benzyloxy)-9H-purin-9-yl)-3-(benzyloxy)-2-(benzyloxymethyl)cyclopentanol-->Benzylchloromethyl ether-->Triethyl orthoformate

Welcome！

Please leave a message for us or use the following ways to contact us, we will reply to you as soon as possible, and provide you with the most sincere service, thank you.

NO. 18 ,Wujiang Road, Wulidian Street, Jiangbei District, Chongqing
+86-23-6139-8061 +86-13650506873
danny@chemdad.com sales@chemdad.com
www.chemdad.com
WhatsApp +86-13650506873