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| CONDURITOL B EPOXIDE Basic information |
| CONDURITOL B EPOXIDE Chemical Properties |
| Melting point | 157-159 | | Boiling point | 360.5±42.0 °C(Predicted) | | density | 1.925±0.06 g/cm3 (20 ºC 760 Torr) | | storage temp. | 2-8°C | | solubility | Soluble in Water (up to 25 mg/ml) or in DMSO | | pka | 13.08±0.70(Predicted) | | form | White solid | | color | White | | Stability: | Moisture Sensitive |
| WGK Germany | 3 | | Hazard Note | Harmful | | HS Code | 2932990090 |
| CONDURITOL B EPOXIDE Usage And Synthesis |
| Description | Conduritol B epoxide (6090-95-5) is a β-Glycosidase inhibitor.1,2 May be used for generation of the “Gaucher mouse”3 and the in vitro model of the Gaucher cell4. | | Chemical Properties | White Crystalline Solid | | Uses | Conduritol B Epoxide acts on b-glucosidases from widely differing sources to show a loss of enzymic activity: from various Aspergillus species, yeast, snail, sweet almonds, and mammals. The other enzymes that have been found to be covalently inhibited are a- glucosidase from yeast and the sucrase-isomaltase complex from rabbit small intestine. | | Uses | inhibitor of glucosidases | | Uses | Conduritol B Epoxide acts on b-glucosidases from widely differing sources to show a loss of enzymic activity: from various Aspergillus species, yeast, snail, sweet almonds, and mammals. The other enzymes that have been found to be covalently inhibited are a- glucosidase from yeast and the sucrase-isomaltase complex from rabbit small intestine. | | General Description | Conduritol B epoxide?(CBE) is a mix of 1-L-1,2-anhydro-myo-inositol and 1-D-1,2-anhydro-myo-inositol. | | Biochem/physiol Actions | Conduritol B epoxide?(CBE)?is capable of inactivating sucrase-isomaltase irreversibly. It can be used to produce cell and animal models to study on Gaucher disease (GD) and Parkinson′s disease (PD). | | References | 1) Datta and Radin (1988), Normalization of liver glucosylceramide levels in the “Gaucher” mouse by phosphatidylserine injection;? Biochem. Biophys. Res. Commun., 152 155
2) Radin and Vunnam (1981), Inhibitors of cerebroside metabolism;? Methods Enzymol., 72 673
3) Stephens et al. (1981), Distribution of conduritol B epoxide in the animal model for gaucher’s disease (Gaucher mouse); Biochim. Biophys. Acta, 672 29
4) Newburg et al. (1986), beta-Glucosidase inhibition in murine peritoneal macrophages by conduritol-B-epoxide: an in vitro model of the Gaucher cell;? Biochim. Biophys. Acta, 877 121 |
| CONDURITOL B EPOXIDE Preparation Products And Raw materials |
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