Other grades of this product :
| HO-PEG5-tBu Basic information |
| Product Name: | HO-PEG5-tBu | | Synonyms: | 1-Hydroxy-3,6,9,12,15-pentaoxaoctadecan-18-oic acid 1,1-dimethylethyl ester;HO-PEG5-CH2CH2COOtBu;HO-PEG5-CH2CH2COOtBu;Hydroxy-PEG5-CH2CO2tBu;HO-PEG5-tBu;OH-PEG5-CH2CH2COOtBu;OH-PEG5-TBA;2-METHYL-2-PROPANYL 1-HYDROXY-3,6,9,12,15-PENTAOXAOCTADECAN-18-OA TE | | CAS: | 850090-09-4 | | MF: | C17H34O8 | | MW: | 366.45 | | EINECS: | | Product Categories: | peg | | Mol File: | 850090-09-4.mol |
| HO-PEG5-tBu Chemical Properties |
| Boiling point | 445.4±40.0 °C(Predicted) | | density | 1.071 | | refractive index | n/D 1.448 | | storage temp. | -20°C | | form | liquid | | pka | 14.36±0.10(Predicted) |
| HO-PEG5-tBu Usage And Synthesis |
| Description | Hydroxy-PEG5-t-butyl ester is a PEG linker containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | | Uses | This heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Hydroxy-PEG5-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation. |
| HO-PEG5-tBu Preparation Products And Raw materials |
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