p-Trifluoromethoxy phenol

p-Trifluoromethoxy phenol
  • CAS No.:828-27-3
Other grades of this product :
p-Trifluoromethoxy phenol Basic information
Uses
Product Name:p-Trifluoromethoxy phenol
Synonyms:PHENOL,4-(TRIFLUOROMETHOXY);TFMOPO;p-Trifluoromethoxy p;4-Hydroxy-alpha,alpha,alpha-trifluoroanisole;4-trifluoroMethoxylphenol;4-(TrifluoroMethoxy)phenol, 98% 1GR;4-TRIFLUOROMETHOXYPHENOL FOR SYNTHESIS;4-(TrifluorMethoxy)benzolol
CAS:828-27-3
MF:C7H5F3O2
MW:178.11
EINECS:212-583-0
Product Categories:alcohol;Trifluoro-methoxy-benzene series;Phenol&Thiophenol&Mercaptan;API intermediates;Organic Building Blocks;Oxygen Compounds;Trifluoroanisole series;Aromatic Hydrocarbons (substituted) & Derivatives;Aromatic Phenols;Phenols;bc0001
Mol File:828-27-3.mol
p-Trifluoromethoxy phenol Chemical Properties
Melting point 17-18°C
Boiling point 92 °C25 mm Hg(lit.)
density 1.375 g/mL at 25 °C(lit.)
refractive index n20/D 1.447(lit.)
Fp 187 °F
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility Chloroform, Methanol
form Liquid
pka9.30±0.13(Predicted)
Specific Gravity1.375
color Clear brown
BRN 1945934
InChIKeyNWVVVBRKAWDGAB-UHFFFAOYSA-N
CAS DataBase Reference828-27-3(CAS DataBase Reference)
NIST Chemistry ReferencePhenol, 4-(trifluoromethoxy)-(828-27-3)
Safety Information
Hazard Codes Xn,Xi
Risk Statements 20/21/22-36/37/38
Safety Statements 26-27-36/37/39
RIDADR 2927
WGK Germany 2
Hazard Note Irritant
HazardClass 6.1
PackingGroup III
HS Code 29095090
MSDS Information
ProviderLanguage
p-Trifluoromethoxy phenol English
SigmaAldrich English
ACROS English
ALFA English
p-Trifluoromethoxy phenol Usage And Synthesis
Uses4-(Trifluoromethoxy)phenol is used as a reactant in the preparation of 1-aryloxyethyl piperazine derivatives as Kv1.5 potassium channel inhibitors.
Chemical Propertiesclear brown liquid
Uses4-(Trifluoromethoxy)phenol is used as a reactant in the preparation of 1-aryloxyethyl piperazine derivatives as Kv1.5 potassium channel inhibitors.
Uses4-(Trifluoromethoxy)phenol was employed in the catalytic enantioselective synthesis of esters.
UsesIntermediates of Liquid Crystals
Synthesis Reference(s)Journal of Medicinal Chemistry, 25, p. 1097, 1982 DOI: 10.1021/jm00351a018
p-Trifluoromethoxy phenol Preparation Products And Raw materials
Preparation Products2-AMINO-4-(TRIFLUOROMETHOXY)PHENOL-->N-Boc-3,4-dihydro-2H-pyridine-->4-(TRIFLUOROMETHOXY)THIOPHENOL

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