Other grades of this product :
| 5-Nitroisatin Chemical Properties |
| Melting point | 251 °C (dec.) (lit.) | | Boiling point | 328.09°C (rough estimate) | | density | 1.5513 (rough estimate) | | refractive index | 1.4900 (estimate) | | storage temp. | Sealed in dry,Room Temperature | | pka | 8.06±0.20(Predicted) | | form | Crystalline Powder | | color | Orange-yellow to orange | | BRN | 180223 | | InChIKey | UNMYHYODJHKLOC-UHFFFAOYSA-N | | CAS DataBase Reference | 611-09-6(CAS DataBase Reference) | | NIST Chemistry Reference | 1H-indole-2,3-dione, 5-nitro-(611-09-6) |
| 5-Nitroisatin Usage And Synthesis |
| Preparation | Isatin 30 (14.7 g, 0.1 mol) was added to conc. H2SO4 (121 ml) cooled to 0 ºC in an ice-salt bath. Fuming HNO3 (4.2 ml) was added to this, drop by drop, in such a way that temperature should not rise above 5 ºC. The reaction mixture was allowed to stand for about 30 minutes and then poured over crushed ice (500 g). A yellow precipitate separated immediately. The 5-Nitroisatin was filtered and washed with water and air dried to a constant weight (15 g). Yield : 85% | | Chemical Properties | orange-yellow to orange crystalline powder | | Uses | Reactant for preparation of:- Potential antibacterial and antifungal agents
- spiro[indole-thiazolidinones] as a medicinally important scaffold
- Potential antimycobacterial agents
- Anticonvulsant agents
- Inhibitors of human transglutaminase 2
- Anthelmintic agents
- Anti-human immunodeficiency virus (HIV) agents
- Antimicrobial agents
- Potential antitubercular agents
- Inhibitors of acetylcholinesterase
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| 5-Nitroisatin Preparation Products And Raw materials |
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