TCO-carbonate

CAS No.：1191901-33-3

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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TCO-carbonate Basic information

Product Name:	TCO-carbonate
Synonyms:	(E)-4-Cycloocten-1-yl 2,5-dioxo-1-pyrrolidinyl ester carbonic acid;(E)-Cyclooct-4-enyl 2,5-dioxo-1-pyrrolidinyl carbonate;TCO-carbonate;TCO-NHS;TCO-N-hydroxysuccinimidyl carbonate;trans-4-Cycloocten-1-yl 2,5-dioxo-1-pyrrolidinyl carbonate;TCO-NHS ester;TCO4 - NHS carbonate / EQUATORIAL isomer
CAS:	1191901-33-3
MF:	C13H17NO5
MW:	267.28
EINECS:
Product Categories:	SiChem
Mol File:	1191901-33-3.mol

TCO-carbonate Chemical Properties

Melting point	90-105°C
Boiling point	369.1±45.0 °C(Predicted)
density	1.27±0.1 g/cm3(Predicted)
storage temp.	-20°C

Safety Information

WGK Germany

MSDS Information

TCO-carbonate Usage And Synthesis

Description

TCO-NHS Ester is an popular reagent to label amine-containing compound or biomolecule, TCOI enable fast click chemistry with tetrazine.

Uses

Succinimidyl carbonate/NHS functionalized cyclooctene derivative for incorporation of the cyclooctene moiety into amine containing compounds or biomolecules. Cyclooctenes are useful in strain-promoted copper-free click chemistry cycloaddition reactions with 1,2,4,5-tetrazines. This cyclooctene will react with tetrazine functionalized compounds or biomolecules without the need for a catalyst to result in a stable covalent linkage. The 4+2 inverse electron demand Diels-Alder cycloaddition between trans-cyclooctene and tetrazines is the fastest biologically compatible ligation technology reported and has had many applications in biological labeling and imaging.

TCO-carbonate Preparation Products And Raw materials

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