| 2-(4-Chlorophenoxy)-2-methylpropionic acid Basic information |
| Product Name: | 2-(4-Chlorophenoxy)-2-methylpropionic acid |
| Synonyms: | CLOFIBRIC ACID;4-Chorophenoxy-d-methylpropionicacid;4-CPIB;Chlorobenzene oxygenisobutyrate;Acetic acid, (p-chlorop;Prestwick_39;2-(4-Chlorophe;Acetic acid, (p-chlorophenoxy)dimethyl- |
| CAS: | 882-09-7 |
| MF: | C10H11ClO3 |
| MW: | 214.65 |
| EINECS: | 212-925-9 |
| Product Categories: | Organic acids;Aromatics Compounds;Acids and Derivatives;Aromatics;Intermediates & Fine Chemicals;Intracellular receptor;Pharmaceuticals;CLOFIBRIN;882-09-7 |
| Mol File: | 882-09-7.mol |
| 2-(4-Chlorophenoxy)-2-methylpropionic acid Chemical Properties |
| Melting point | 120-122 °C(lit.) |
| Boiling point | 308.11°C (rough estimate) |
| density | 1.2413 (rough estimate) |
| refractive index | 1.5220 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform, Methanol |
| form | Crystals or Crystalline Powder |
| pka | 3.18±0.10(Predicted) |
| color | Pale yellow to brownish |
| Merck | 14,2378 |
| BRN | 1874067 |
| CAS DataBase Reference | 882-09-7(CAS DataBase Reference) |
| NIST Chemistry Reference | Clofibric acid(882-09-7) |
| EPA Substance Registry System | Propanoic acid, 2-(4-chlorophenoxy)-2-methyl- (882-09-7) |
| Safety Information |
| Hazard Codes | Xn,Xi |
| Risk Statements | 22-20/21/22 |
| Safety Statements | 36-24/25 |
| WGK Germany | 3 |
| RTECS | UE9455000 |
| HazardClass | IRRITANT |
| HS Code | 29189900 |
| MSDS Information |
| Provider | Language |
|---|---|
| SigmaAldrich | English |
| ACROS | English |
| ALFA | English |
| 2-(4-Chlorophenoxy)-2-methylpropionic acid Usage And Synthesis |
| Description | Clofibric acid is a peroxisome proliferator-activated receptor α (PPARα) agonist (EC50 = 50 μM in a transactivation assay) and the active metabolite of clofibrate . It is formed from clofibrate by tissue and serum esterases. Dietary administration of clofibric acid (0.067-0.22%) reduces serum cholesterol, phospholipid, and triglyceride levels in rats. It decreases glutamate oxaloacetate transaminase (GOT) levels and increases glutamate pyruvate transaminase (GPT) and lactate dehydrogenase (LDH) levels, markers of xenobiotic stress, in the plasma of carp (C. carpio) when administered in tank water at a concentration of 10 μg/L. Clofibric acid has been found in wastewater effluent. |
| Chemical Properties | Pale Yellow Solid |
| Uses | Antilipemic. |
| Uses | herbicide, antihyperlipoproteinemic, antineoplastic |
| Uses | A hypolipidemic compound |
| Definition | ChEBI: A monocarboxylic acid that is isobutyric acid substituted at position 2 by a p-chlorophenoxy group. It is a metabolite of the drug clofibrate. |
| Biological Activity | PPAR agonist. Antihyperlipoproteinemic. |
| 2-(4-Chlorophenoxy)-2-methylpropionic acid Preparation Products And Raw materials |
| Raw materials | O-(4-chlorophenyl)hydroxylamine-->plafibride-->Chlorobutanol-->4-CHLOROPHENOL SODIUM SALT-->N-Acetyl-L-cysteine-->4-Chlorophenol-->Ethyl 2-bromoisobutyrate-->Acetone-->Chloroform-->Acetamide |
| Preparation Products | Clofibrate-->etofibrate 2-hydroxymethylnicotinate-->Nicotinic acid |
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