N-Methylbenzamide

CAS No.：613-93-4

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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N-Methylbenzamide Basic information

Product Name:	N-Methylbenzamide
Synonyms:	N-METHYLBENZAMIDE;n-methyl-benzamid;N-Methylbenzenamide;n-methylbenzenecarboxamide;N-METHYLBENZAMIDE, 99+%;Benzamide, N-methyl- (6CI,7CI,8CI,9CI);N-MethylbenzaMide, 99+% 10GR;Benzamide, N-methyl-
CAS:	613-93-4
MF:	C8H9NO
MW:	135.16
EINECS:	210-362-3
Product Categories:	Amides;Carbonyl Compounds;AMIDE;Organic Building Blocks;613-93-4
Mol File:	613-93-4.mol

N-Methylbenzamide Chemical Properties

Melting point	76-78 °C (lit.)
Boiling point	167 °C/11 mmHg (lit.)
density	1.1031 (rough estimate)
refractive index	1.5589 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	ethanol: soluble50mg/mL, clear, yellow-green
pka	15.00±0.46(Predicted)
Water Solubility	Insoluble in water.
CAS DataBase Reference	613-93-4(CAS DataBase Reference)
EPA Substance Registry System	N-Methylbenzamide (613-93-4)

Safety Information

Hazard Codes	Xn
Risk Statements	20/21/22-22
Safety Statements	24/25
WGK Germany	1
RTECS	CV5570000
TSCA	Yes
HS Code	29242990

MSDS Information

Provider	Language
SigmaAldrich	English
ACROS	English
ALFA	English

N-Methylbenzamide Usage And Synthesis

Chemical Properties	N-methylbenzamide is an off-white crystalline solid.
Uses	N-Methylbenzamide is an important pesticide intermediate. It acts as a potent PDE10A (phosphodiesterase with a remarkable localization as the protein is abundant only in brain tissue) inhibitor.
Synthesis Reference(s)	Synthetic Communications, 7, p. 549, 1977 DOI: 10.1080/00397917709409275Tetrahedron Letters, 30, p. 451, 1989 DOI: 10.1016/S0040-4039(00)95225-0
General Description	N-Methylbenzamide is a potent PDE10A (phosphodiesterase with a remarkable localization as the protein is abundant only in brain tissue) inhibitor.
Air & Water Reactions	Insoluble in water.
Reactivity Profile	N-METHYLBENZAMIDE is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).
Fire Hazard	Flash point data concerning N-METHYLBENZAMIDE are not available, however, N-METHYLBENZAMIDE is probably combustible.

N-Methylbenzamide Preparation Products And Raw materials

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