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| 4,6-DIOXOHEPTANOIC ACID Basic information |
| Product Name: | 4,6-DIOXOHEPTANOIC ACID | | Synonyms: | 4,6-DIOXOHEPTANOIC ACID;SUCCINYLACETONE;Succinylacetone-3,4,5,6,7-13C5;4,6-Dioxoheptanoic acid-3,4,5,6,7-13C5;[13C7]-Succinylacetone;Heptanoic acid, 4,6-dioxo-;4,6-dioxoheptanoicaci | | CAS: | 51568-18-4 | | MF: | C7H10O4 | | MW: | 158.15 | | EINECS: | | Product Categories: | Aliphatics;Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 51568-18-4.mol |
| 4,6-DIOXOHEPTANOIC ACID Chemical Properties |
| Melting point | 66-67 °C(lit.) | | Boiling point | 318.7±17.0 °C(Predicted) | | density | 1.189±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) | | form | powder | | pka | 4.54±0.17(Predicted) | | color | White to Off-White | | CAS DataBase Reference | 51568-18-4 |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 |
| 4,6-DIOXOHEPTANOIC ACID Usage And Synthesis |
| Chemical Properties | White Solid | | Uses | Succinylacetone (SA) is a specific marker for the inherited metabolic disease, hepatorenal tyrosinemia. It was developed a stable-isotope
quid urine using a 13C4-SA as internal standard. | | Uses | 4,6-Dioxoheptanoic acid has been used:- as component of dendritic cell conditioning medium and in the inhibition of ALA dehydratase (ALAD) in dendritic cells(50)
- as an inhibitor of heme biosynthesis in human mononuclear cells(51) and HeLa cells(52)
- as a standard for the quantification of succinylacetone from Plasmodium falciparum cultures(53)
| | Definition | ChEBI: A dioxo monocarboxylic acid that is heptanoic acid in which oxo groups replace the hydrogens at positions 4 and 6. It is an abnormal metabolite of the tyrosine metabolic pathway and a marker for type 1 tyrosinaemia. | | Biochem/physiol Actions | 4,6-Dioxoheptanoic acid is an inhibitor of heme biosynthesis. It is a catabolic byproduct of tyrosine breakdown and inhibits δ-aminolevulinic acid (ALA) dehydratase enzyme. It is a potential marker for detecting tyrosinemia type I and is measured in dried blood spot of new borns. |
| 4,6-DIOXOHEPTANOIC ACID Preparation Products And Raw materials |
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