Product

Ethyl (R)-2-hydroxy-4-phenylbutyrate

CAS No.：90315-82-5

Other grades of this product :

Ethyl (R)-2-hydroxy-4-phenylbutyrate Basic information

Product Name:	Ethyl (R)-2-hydroxy-4-phenylbutyrate
Synonyms:	ETHYL-[(R)-(-)-2-HYDROXY-4-PHENYLBUTYRAT];ETHYL (R)-(-)-2-HYDROXY-4-PHENYLBUTYRATE;ETHYL (R)-2-HYDROXY-4-PHENYLBUTYRATE;Ethyl(R)-2-Hydroxyl-4-PhenylButyrate;ethyl (2R)-2-hydroxy-4-phenylbutanoate;ETHYL(R)-2-HYDROXY-4-PHENYLBUTANOATE;R-(-)-2-Hydroxy-4-Phenyl-Butyric Acid Ethyl Ester (R-Hpbe);(R)-2-Hydroxy-4-phenylbutanoicacidethylester
CAS:	90315-82-5
MF:	C12H16O3
MW:	208.26
EINECS:	618-525-4
Product Categories:	Chiral Building Blocks;Esters (Chiral);Synthetic Organic Chemistry;Chiral Building Blocks;Esters;Organic Building Blocks;Alcohols, Hydroxy Esters and Derivatives;chiral;(intermediate of benazepril hydrochloride);(intermediate of lisinopril );API;Aromatics;Chiral Reagents;Intermediates;Chiral Compounds
Mol File:	90315-82-5.mol

Ethyl (R)-2-hydroxy-4-phenylbutyrate Chemical Properties

Melting point	NA
Boiling point	212 °C(lit.)
alpha	-10 º (c=neat)
density	1.075 g/mL at 20 °C(lit.)
refractive index	n20/D 1.504(lit.)
Fp	>230 °F
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	Chloroform (Slightly), Methanol (Slightly)
pka	13.00±0.20(Predicted)
form	Liquid
color	Colorless
optical activity	[α]21/D 10°, neat
Water Solubility	insoluble
BRN	3590943
InChIKey	ZJYKSSGYDPNKQS-LLVKDONJSA-N
CAS DataBase Reference	90315-82-5(CAS DataBase Reference)

Safety Information

Safety Statements	23-24/25
WGK Germany	3
HS Code	29181990

MSDS Information

Provider	Language
Ethyl (R)-2-hydroxy-4-phenylbutyrate	English
SigmaAldrich	English
ACROS	English

Ethyl (R)-2-hydroxy-4-phenylbutyrate Usage And Synthesis

Chemical Properties	Colorless to light yellow liqui
Uses	Ethyl(R)-2-hydroxy-4-phenylbutyrate is used in the preparation of benzothiophenes, benzofurans, and indoles useful in the treatment of insulin resistance and hyperglycemia.
Uses	Ethyl (R)-(?)-2-hydroxy-4-phenylbutyrate can be used as a key intermediate for the synthesis of various ACE inhibitors like Cilazapril, Benazepril, and Enalapril.

Ethyl (R)-2-hydroxy-4-phenylbutyrate Preparation Products And Raw materials

Raw materials

Ethanol-->Hydrochloric acid-->Ethyl acetate-->Methanol-->Diethyl ether-->Sulfuric acid-->PETROLEUM ETHER-->Toluene-->Magnesium sulfate-->Potassium hydroxide-->Sodium bicarbonate-->Benzene-->Benzaldehyde-->Pyruvic acid-->Palladium (II) Acetate-->p-Toluenesulfonic acid monohydrate-->3-Indolepropionic acid-->(+)-MENTHOL

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