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| Imidapril Basic information |
| Product Name: | Imidapril | | Synonyms: | (s)-3-(n-((s)-1-ethoxycarbonyl-3-phenylpropyl)-l-alanyl)-1-methyl-2-oxoimidazoline-4-carboxylic acid;IMIDAPRIL;(4S)-3-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1-methyl-2-oxo-4-imidazolidinecarboxylic Aci;4-Imidazolidinecarboxylic acid, 3-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1-methyl-2-oxo-, (4S)-;4-Imidazolidinecarboxylic acid, 3-[2-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1-methyl-2-oxo-, [4S-[3[R*(R*)],4R*]]-;(4S)-3-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1-methyl-2-oxo-4-imidazolidinecarboxylic Acid Hydrochloride;(4S)-3-[(2S)-2-[N-[(1S)-1-(Ethyoxycarbonyl)-3-phenylpropyl]amino]propionyl]-1-methyl-2-oxoimidazolidine-4-carboxylic acid;lmidaprfil | | CAS: | 89371-37-9 | | MF: | C20H27N3O6 | | MW: | 405.44 | | EINECS: | | Product Categories: | Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 89371-37-9.mol |
| Imidapril Chemical Properties |
| Melting point | 195-197°C | | alpha | D20 -71.7° (c = 0.5 in ethanol) | | Boiling point | 577.0±60.0 °C(Predicted) | | density | 1.266±0.06 g/cm3(Predicted) | | storage temp. | -20°C Freezer | | pka | 2.44±0.20(Predicted) | | CAS DataBase Reference | 89371-37-9(CAS DataBase Reference) |
| Imidapril Usage And Synthesis |
| Description | Imidapril is a new ACE inhibitor launched in Japan as a once-daily therapy for
hypertension. Its active metabolite has more potent inhibitory effects on all tissue ACES from
spontaneously hypertensive rats (SHRs) and Wistar Kyoto rats (WKYs) than many other ACE
inhibitors including enalapril and captopril. It has a very long duration of action. In strokeprone
spontaneously hypertensive rats (SHRSP), imidapril is effective in stroke prevention at
a considerably lower dose than enalapril. This stroke preventive effect has been suggested to
be primarily by an indirect mechanism related to the amelioration of kidney dysfunction. | | Chemical Properties | White Solid | | Originator | Tanabe (Japan) | | Uses | Angiotensin converting enzyme (ACE) inhibitor. Antihypertensive | | Brand name | Tanatril; Novarok |
| Imidapril Preparation Products And Raw materials |
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