N-Carbobenzyloxy-L-alanine

CAS No.：1142-20-7

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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N-Carbobenzyloxy-L-alanine Basic information

Product Name:	N-Carbobenzyloxy-L-alanine
Synonyms:	N-CBZ-L-ALANINE;N-CBZ-L-ALANINE-OH;N-CARBOBENZYLOXY-L-ALANINE;N-ALPHA-BENZYLOXYCARBONYL-L-ALANINE;N-ALPHA-CARBOBENZOXY-L-ALANINE;N-ALPHA-CBZ-L-ALANINE;N-BENZYLOXYCARBONYL-L-ALANINE;N-CARBOBENZOXY-L-ALANINE
CAS:	1142-20-7
MF:	C11H13NO4
MW:	223.23
EINECS:	214-532-8
Product Categories:	Alanine [Ala, A];Z-Amino Acids and Derivatives;Amino Acids;Amino Acids (N-Protected);Biochemistry;Cbz-Amino Acids;Protected Amino Acids;PROTECTED AMINO ACID & PEPTIDES;Chiral Compounds;Z-Amino acid series;bc0001
Mol File:	1142-20-7.mol

N-Carbobenzyloxy-L-alanine Chemical Properties

Melting point	84-87 °C
alpha	-15 º (c=2, AcOH 24 ºC)
Boiling point	364.51°C (rough estimate)
density	1.2446 (rough estimate)
refractive index	-14.5 ° (C=2, AcOH)
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
pka	4.00±0.10(Predicted)
form	Powder
color	White
optical activity	[α]23/D 14.2°, c = 2 in acetic acid
BRN	2056164
InChIKey	TYRGLVWXHJRKMT-QMMMGPOBSA-N
CAS DataBase Reference	1142-20-7(CAS DataBase Reference)

Safety Information

Hazard Codes	Xn
Risk Statements	20/21/22-36/37/38
Safety Statements	22-24/25-36-26
WGK Germany	3
HazardClass	IRRITANT
HS Code	29242990

MSDS Information

Provider	Language
N-CBZ-L-Alanine	English
SigmaAldrich	English
ACROS	English
ALFA	English

N-Carbobenzyloxy-L-alanine Usage And Synthesis

Chemical Properties	white powder
Uses	N-Benzyloxycarbonyl-L-alanine is an intermediate in the synthesis of Perindopril (P287500), an angiotensin-converting enzyme (ACE) inhibitor. Antihypertensive.

N-Carbobenzyloxy-L-alanine Preparation Products And Raw materials

Preparation Products

DELAPRIL-->N-Cbz-D-Alanine-->(S)-4-Methyl-2,5-oxazolidonedione

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