Product

(S)-(+)-3-Hydroxytetrahydrofuran

CAS No.：86087-23-2

Other grades of this product :

(S)-(+)-3-Hydroxytetrahydrofuran Basic information

Product Name:	(S)-(+)-3-Hydroxytetrahydrofuran
Synonyms:	(S)-TETRAHYDROFURAN-3-OL;(S)-(+)-TETRAHYDRO-3-FURANOL;(S)-(+)-3-HYDROXY TETAHYDRO FURAN;(S)-(-)-3-HYDROXY TETRAHYDRO FURAN;(3S)-oxolan-3-ol;(2S)-1,4-Epoxy-2-hydroxybutane, (3S)-Tetrahydrofuran-3-ol, (3S)-Oxolan-3-ol;Afatinib intermediate B;(S)-(+)-3-Hydroxytetrahydrofuran, ee: 95%
CAS:	86087-23-2
MF:	C4H8O2
MW:	88.11
EINECS:	425-090-2
Product Categories:	Afatinib intermediate;Chiral Building Blocks;Chiral Reagents;Furans;Simple Alcohols (Chiral);Synthetic Organic Chemistry;Alcohols, Hydroxy Esters and Derivatives;Chiral Compounds;Starting Raw Materials & Intermediates;Small molecule;Tetrahydrofuran Series;bc0001
Mol File:	86087-23-2.mol

(S)-(+)-3-Hydroxytetrahydrofuran Chemical Properties

Boiling point	80 °C/15 mmHg (lit.)
alpha	18.5 º (c=2 MeOH)
density	1.103 g/mL at 25 °C (lit.)
vapor pressure	47Pa at 25℃
refractive index	n20/D 1.45(lit.)
Fp	175 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Chloroform, Methanol (Slightly)
pka	14.49±0.20(Predicted)
form	Liquid
Specific Gravity	1.11
color	Clear colorless to pale yellow
optical activity	[α]20/D +17.5°, c = 2.4 in methanol
Water Solubility	soluble
BRN	4652609
Stability:	Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey	XDPCNPCKDGQBAN-BYPYZUCNSA-N
LogP	-0.784 at 22℃ and pH6.8
Surface tension	72mN/m at 1g/L and 25℃
CAS DataBase Reference	86087-23-2(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-37/39
RIDADR	NA 1993 / PGIII
WGK Germany	3
HS Code	29321900

MSDS Information

Provider	Language
SigmaAldrich	English
ACROS	English

(S)-(+)-3-Hydroxytetrahydrofuran Usage And Synthesis

Chemical Properties	Colourless Liquid
Uses	Amprenavir and Fosamprenavir intermediate
Uses	(S)-(+)-3-Hydroxytetrahydrofuran is a useful reagent for the preparation of pyrazolo triazin ylamine derivatives as adenosine receptor antagonists.

(S)-(+)-3-Hydroxytetrahydrofuran Preparation Products And Raw materials

Raw materials	Ethanol-->Ethyl acetate-->Methanol-->Tetrahydrofuran-->Toluene-->Lithium Aluminum Hydride-->p-Toluenesulfonic acid-->L-Malic acid
Preparation Products	(R)-(-)-3-Hydroxytetrahydrofuran-->(S)-3-P-MESYLOXYTETRAHYDROFURAN

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