Product

Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate

CAS No.：160844-75-7

Other grades of this product :

Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate Basic information

Product Name:	Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate
Synonyms:	Febuxostat Ethyl Ester Impurity;Febuxostat Impurity 15/Febuxostat Ethyl Ester/Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate;Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazol;Febuxostat-7;5-Thiazolecarboxylicacid, 2-[3-cyano-4-(2-Methylpropoxy)phenyl]-4-Methyl-, ethyl ester;2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate;Febuxostat Ethyl Ester;ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl
CAS:	160844-75-7
MF:	C18H20N2O3S
MW:	344.43
EINECS:	927-913-5
Product Categories:	Febuxostat Intermediates;Febuxostat intermediate
Mol File:	160844-75-7.mol

Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate Chemical Properties

Melting point	176 °C
Boiling point	497.1±55.0 °C(Predicted)
density	1.22
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO (Slightly, Heated), Methanol (Very Slightly, Heated)
form	Solid
pka	1.02±0.10(Predicted)
color	White to Off-White
CAS DataBase Reference	160844-75-7(CAS DataBase Reference)

Safety Information

MSDS Information

Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate Usage And Synthesis

Chemical Properties	White crystalline powder
Uses	Ethyl 2-(3-Cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate is an impurity of Febuxostat (F229000), a xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.

Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate Preparation Products And Raw materials

Raw materials

5-iodo-2-isobutoxybenzonitrile-->ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE-->ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate-->ethyl 2-(4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate-->Ethyl 2-(3-bromo-4-isobutoxyphenyl)- 4-methyl-5-thiazolecarboxylate-->5-bromo-2-isobutoxy benzonitirle-->3-Cyano-4-(2-methylpropoxy)benzenecarbothioamide-->(3-cyano-4-isobutoxyphenyl)boronic acid-->Febuxostat Impurity 6-->ETHYL 2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE-->Ethyl 4-methyl-5-thiazoleactate-->Ethyl 2-(3-Cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate-->5-Bromo-2-fluorobenzonitrile-->1-Bromo-2-methylpropane

Welcome！

Please leave a message for us or use the following ways to contact us, we will reply to you as soon as possible, and provide you with the most sincere service, thank you.

NO. 18 ,Wujiang Road, Wulidian Street, Jiangbei District, Chongqing
+86-23-6139-8061 +86-13650506873
danny@chemdad.com sales@chemdad.com
www.chemdad.com
WhatsApp +86-13650506873