Cefmetazole sodium

CAS No.：56796-39-5

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Cefmetazole sodium Basic information

Product Name:	Cefmetazole sodium
Synonyms:	Cefmetazone;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[[(cyanomethyl)thio]acetyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, monosodium salt, (6R,7S)-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[[(cyanomethyl)thio]acetyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, monosodium salt, (6R-cis)-;Cefmetazole-Na;CS-1170 sodium salt;Metafar;Sodium cefmetazole;(6R,7S)-7-[[2-[(Cyanomethyl)thio]acetyl]amino]-7-methoxy-3-[[(1-methyl -1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene -2-carboxylic Acid Sodium Salt
CAS:	56796-39-5
MF:	C15H18N7NaO5S3
MW:	495.52
EINECS:	627-393-7
Product Categories:	Sulfur & Selenium Compounds;A - KAntibiotics;Antibacterial;Antibiotics A to;Antibiotics A-FAntibiotics;Chemical Structure Class;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Interferes with Cell Wall SynthesisAntibiotics;Mechanism of Action;Penicillins and Cephalosporins (beta-Lactams);Spectrum of Activity
Mol File:	56796-39-5.mol

Cefmetazole sodium Chemical Properties

Melting point	>130°C (dec.)
storage temp.	Inert atmosphere,2-8°C
solubility	H2O: soluble50mg/mL
form	powder
color	White to Off-White
Water Solubility	Soluble in water
Sensitive	Hygroscopic
Merck	14,1926
InChIKey	BITQGIOJQWZUPL-PBCQUBLHSA-M
CAS DataBase Reference	56796-39-5(CAS DataBase Reference)

Safety Information

Hazard Codes	Xn,Xi
Risk Statements	36/37/38-42/43
Safety Statements	26-36
WGK Germany	2
RTECS	XI0372200
Toxicity	LD50 i.v. in rats: >5000 mg/kg (Masuda)

MSDS Information

Cefmetazole sodium Usage And Synthesis

Chemical Properties	White Solid
Uses	Semi-synthetic antibiotic derived from Cephamycin. Antibacterial
Uses	Cefmetazole sodium is used clinically in combination with Tanreqing for the treatment of Pulmonary infections like Senile Emphysema and other acute bacterial infections.
Definition	ChEBI: An organic sodium salt that is the sodium salt of cefmetazole.
Brand name	Zefazone (Pharmacia & Upjohn）.
Clinical Use	Cefmetazole (Zefazone) is a semisynthetic, third-generation,parenteral cephalosporin of the cephamycin group. Likeother cephamycins, the presence of the 7α-methoxyl groupconfers resistance to many β-lactamases. Cefmetazoleexhibits significantly higher potency against members ofthe Enterobacteriaceae family but lower activity againstBacteroides spp. than cefoxitin. It is highly active againstN. gonorrhoeae, including -lactamase–producing strains. Incommon with other cephamycins, cefmetazole is ineffectiveagainst indole-positive Proteus, Enterobacter, Providencia,Serratia, and Pseudomonas spp. Cefmetazole has the MTTmoiety associated with increased bleeding in certain highriskpatients. It has a plasma half-life of 1.1 hours.

Cefmetazole sodium Preparation Products And Raw materials

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