2-[2-(2-methoxyethoxy)ethoxy]-ethanethiol

CAS No.：31521-83-2

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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2-[2-(2-methoxyethoxy)ethoxy]-ethanethiol Basic information

Product Name:	2-[2-(2-methoxyethoxy)ethoxy]-ethanethiol
Synonyms:	2-Methoxy[2-ethoxy(2-ethoxy)]-1-ethanethiol;m-PEG3-thiol;Thiol-PEG3-methyl;MPEG3-SH;2-[2-(2-methoxyethoxy)ethoxy]-ethanethiol;2-<2-(2-methoxyethoxy)ethoxy>ethylthiol;Ethanethiol, 2-[2-(2-methoxyethoxy)ethoxy]-;1-(1-Ethoxyethoxy)-2-methoxyethanethiol
CAS:	31521-83-2
MF:	C7H16O3S
MW:	180.27
EINECS:
Product Categories:	peg
Mol File:	31521-83-2.mol

2-[2-(2-methoxyethoxy)ethoxy]-ethanethiol Chemical Properties

Boiling point	50 °C(Press: 1 Torr)
density	1.017
pka	9.65±0.10(Predicted)

Safety Information

HS Code

3404200000

MSDS Information

2-[2-(2-methoxyethoxy)ethoxy]-ethanethiol Usage And Synthesis

Synthesis

Toluene-4-sulfonic acid 2-[2-(2-methoxyethoxy)-ethoxy]-ethyl ester (2.7) (10.8 g, 34 mmol) and thiourea (2.6 g, 34 mmol) were dissolved in a mixture of absolute EtOH (20 mL) and H2O (14 mL) and the mixture was refluxed for 3h. 4N NaOH solution (10 mL) was added to mixture and the reaction mixture refluxed 2 more h. The reaction mixture was concentrated under reduced pressure to ~ 10 mL, diluted with distilled H2O (10 mL) and neutralized with concentrated HCl. The solution was extracted with CH2Cl2 (3x10mL) and the solvent was evaporated under reduced pressure. The pink-yellow liquid was distilled at 0.45 torr pressure. The product was collected as a clear liquid and obtained in 54% yield. B.p. 55-57 °C at 0.45 torr. GC-MS Calcd. C7H16O3S+ : 180.0; found: 179.9. 1 H NMR (250 MHz, CDCl3) δ 3.6(6H), 3.5(4H), 3.4(3H), 2.7(2H), 1.6(1H); 13 C NMR (300 MHz, CDCl3) δ 76.92, 73.30, 72.34, 70.98, 70.63, 59.46, 24.66

2-[2-(2-methoxyethoxy)ethoxy]-ethanethiol Preparation Products And Raw materials

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