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| 5-Chloro-3-nitropyrazolo[1,5-a]pyriMidine Basic information |
| Product Name: | 5-Chloro-3-nitropyrazolo[1,5-a]pyriMidine | | Synonyms: | 5-Chloro-3-nitropyrazolo[1,5-a]pyriMidine;Pyrazolo[1,5-a]pyrimidine, 5-chloro-3-nitro-;5-Chloro-3-nitropyrazolo[1,5-a]pyriMidin;5-Chloro-3-nitropyrazolo[...;Larotrectinib Impurity 1（Larotrectinib CNPP Impurity）;arotrectinib CNPP Impurity;5-chloro-3-nitropyrazole [1,5-a] pyrimidine | | CAS: | 1363380-51-1 | | MF: | C6H3ClN4O2 | | MW: | 198.57 | | EINECS: | | Product Categories: | | Mol File: | 1363380-51-1.mol |
| 5-Chloro-3-nitropyrazolo[1,5-a]pyriMidine Chemical Properties |
| Melting point | 163 - 165°C | | density | 1.85±0.1 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | solubility | Chloroform (Slightly, Heated), DMSO (Slightly) | | form | Solid | | pka | -3.59±0.40(Predicted) | | color | Purple |
| 5-Chloro-3-nitropyrazolo[1,5-a]pyriMidine Usage And Synthesis |
| Uses | 5-Chloro-3-nitro-pyrazolo[1,5-a]pyrimidine is used in the preparation of (S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide, a tyrosine kinase (TRK) inhibitor for treating cancer. |
| 5-Chloro-3-nitropyrazolo[1,5-a]pyriMidine Preparation Products And Raw materials |
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![5-Chloro-3-nitropyrazolo[1,5-a]pyriMidine](/img/1363380-51-1.jpg "5-Chloro-3-nitropyrazolo[1,5-a]pyriMidine")
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