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| Amino-PEG5-t-butyl ester Basic information |
| Product Name: | Amino-PEG5-t-butyl ester | | Synonyms: | Amino-PEG5-t-butyl ester;4,7,10,13,16-Pentaoxaoctadecanoic acid, 18-amino-, 1,1-dimethylethyl ester;H2N-PEG5-CH2CH2COOtBu;NH2-PEG5-CH2CH2COOtBu;Amino-PEG5-COOtBu;tert-butyl 1-amino-3,6,9,12,15-pentaoxaoctadecan-18-oate;Amino-PEG5-Boc;Amino-PEG5-t-Bu Ester | | CAS: | 1446282-18-3 | | MF: | C17H35NO7 | | MW: | 365.46 | | EINECS: | | Product Categories: | peg | | Mol File: | 1446282-18-3.mol |
| Amino-PEG5-t-butyl ester Chemical Properties |
| Boiling point | 439.1±40.0 °C(Predicted) | | density | 1.049±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | Soluble in Water, DMSO, DCM, DMF | | pka | 8.74±0.10(Predicted) |
| Amino-PEG5-t-butyl ester Usage And Synthesis |
| Description | Amino-PEG5-t-butyl ester is a PEG molecule consisting of an amino group and a t-butyl protected carboxyl group. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The t-butyl protected carboxyl group can be deprotected under acidic conditions.The hydrophilic PEG spacer increases solubility in aqueous media. | | Uses | This heterobifunctional, PEGylated crosslinker features an amino group at one end and t-butyl-protected carboxyl group at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Amino-PEG5-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation. |
| Amino-PEG5-t-butyl ester Preparation Products And Raw materials |
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