Other grades of this product :
| NSC 361680 Basic information |
| Product Name: | NSC 361680 | | Synonyms: | 3,3'-Oxybis[propanoic acid];3,3'-Oxydipropionic acid;Bis(2-carboxyethyl) ether;NSC 361680;Bis-PEG1-acid;3-(2-carboxyethoxy)propanoic acid;Propanoic acid, 3,3'-oxybis-;CAS_5961-83-1 | | CAS: | 5961-83-1 | | MF: | C6H10O5 | | MW: | 162.14 | | EINECS: | | Product Categories: | | Mol File: | 5961-83-1.mol |
| NSC 361680 Chemical Properties |
| Melting point | 60-61 °C | | Boiling point | 198-200 °C(Press: 1-2 Torr) | | density | 1.316±0.06 g/cm3(Predicted) | | storage temp. | -20°C Freezer, Under inert atmosphere | | solubility | Aqueous Base (Slightly), Chloroform (Slightly), Methanol (Slightly), Water (Slig | | form | Solid | | pka | 3.96±0.10(Predicted) | | color | Pale Yellow to Light Yellow |
| NSC 361680 Usage And Synthesis |
| Description | Bis-PEG1-acid is a PEG linker containing two terminal carboxylic acid groups. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acids can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. | | Uses | Bis-PEG1-acid is a PEG-based PROTAC linker and can be used in the synthesis of PROTACs as BCL-xL degraders and anticancer agents with low platelet toxicity. |
| NSC 361680 Preparation Products And Raw materials |
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