Product

1-Methylindole-2-carboxylic acid

CAS No.：16136-58-6

Other grades of this product :

1-Methylindole-2-carboxylic acid Basic information

Product Name:	1-Methylindole-2-carboxylic acid
Synonyms:	RARECHEM AL BE 0864;N-METHYL-2-INDOLECARBOXYLIC ACID;1H-Indole-2-carboxylic acid, 1-methyl-;1-methyl-1h-indole-2-carboxylicaci;1-Methyl-2-indolecarboxylic acid;1-methyl-2-indolecarboxylicacid;Indole-2-carboxylic acid, 1-methyl-;AKOS JY2082906
CAS:	16136-58-6
MF:	C10H9NO2
MW:	175.18
EINECS:
Product Categories:	Building Blocks;C10;Building Blocks;Heterocyclic Building Blocks;Chemical Synthesis;Heterocyclic Building Blocks;Indoles and derivatives;Organic acids;Indoles
Mol File:	16136-58-6.mol

1-Methylindole-2-carboxylic acid Chemical Properties

Melting point	212-213 °C (dec.) (lit.)
Boiling point	389.0±15.0 °C(Predicted)
density	1.24±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
form	Crystalline Powder
pka	4.19±0.30(Predicted)
color	Beige
CAS DataBase Reference	16136-58-6(CAS DataBase Reference)
NIST Chemistry Reference	1-Methylindole-2-carboxylic acid(16136-58-6)

Safety Information

Hazard Codes	Xn,Xi
Risk Statements	22-36/37/38
Safety Statements	26
WGK Germany	3
RTECS	NL6012400
HazardClass	IRRITANT
HS Code	29339980

MSDS Information

Provider	Language
SigmaAldrich	English

1-Methylindole-2-carboxylic acid Usage And Synthesis

Chemical Properties	Beige crystalline powder
Uses	• ;Reactant for preparation of keto-indoles as novel indoleamine 2,3-dioxygenase (IDO) inhibitors1• ;Reactant for synthesis of fenbufen and ethacrynic acid derivatives as potential antitumor agents via amide coupling reactions2• ;Reactant for diastereoselective synthesis of vinylated heterocycles via ruthenium-catalyzed oxidative vinylation with alkenes3• ;Reactant for synthesis of 2,3-dihalo indoles via hypervalent iodine mediated decarboxylative halogenation4• ;Reactant for preparation of α-ketoamides as cathepsin S inhibitors with potential applications ag
Uses	Reactant for preparation of keto-indoles as novel indoleamine 2,3-dioxygenase (IDO) inhibitors Reactant for synthesis of fenbufen and ethacrynic acid derivatives as potential antitumor agents via amide coupling reactions Reactant for diastereoselective synthesis of vinylated heterocycles via ruthenium-catalyzed oxidative vinylation with alkenes Reactant for synthesis of 2,3-dihalo indoles via hypervalent iodine mediated decarboxylative halogenation Reactant for preparation of α-ketoamides as cathepsin S inhibitors with potential applications against tumor invasion and angiogenesis Reactant for preparation of anthranilic acid mimics as bacterial translation inhibitors
General Description	1-Methylindole-2-carboxylic acid reacts with thionyl chloride to yield sulfinyl chlorides.

1-Methylindole-2-carboxylic acid Preparation Products And Raw materials

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