Mafenide hydrochloride

CAS No.：138-37-4

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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Mafenide hydrochloride Basic information

Product Name:	Mafenide hydrochloride
Synonyms:	masudin;morfanil;p-aminomethylphenylsulfonamidehydrochloride;sulfamylonhydrochloride;sulfbenzaminehydrochloride;MARFANIL;MARFANIL HYDROCHLORIDE;MAFENIDE HYDROCHLORIDE
CAS:	138-37-4
MF:	C7H11ClN2O2S
MW:	222.69
EINECS:	205-325-3
Product Categories:
Mol File:	138-37-4.mol

Mafenide hydrochloride Chemical Properties

Melting point	261-263 °C(lit.)
storage temp.	Inert atmosphere,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
form	neat
color	White
Merck	13,5671
InChIKey	SIACJRVYIPXFKS-UHFFFAOYSA-N
CAS DataBase Reference	138-37-4(CAS DataBase Reference)

Safety Information

Hazard Codes	Xn
Risk Statements	42/43
Safety Statements	22-36/37-45
WGK Germany	2
RTECS	XT5425000
HS Code	29350090
Toxicity	LD50 in rats, mice (mg/kg): 1170, 900 i.v. (Skulan, Hoppe)

MSDS Information

Provider	Language
SigmaAldrich	English

Mafenide hydrochloride Usage And Synthesis

Uses	Antibacterial;Inhibitor of folic acid biosynthesis
Purification Methods	Crystallise the salt from dilute HCl or 95% EtOH and dry it in a vacuum at 100o. It is an antibacterial. [Miller et al. J Am Chem Soc 62 2099 1940, Bergeim & Barker J Am Chem Soc 66 1459 1944.] The sulfate salt has m 254-255o (from aqueous EtOH). [Beilstein 14 III 2223, 14 IV 2799.]

Mafenide hydrochloride Preparation Products And Raw materials

Raw materials

Ethanol-->Hydrochloric acid-->Ethyl acetate-->Sulfuric acid-->Dichloromethane-->Chloroform-->Triethylamine-->Ammonia-->Acetyl chloride-->Chlorosulfonic acid-->Benzylamine

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