S-NITROSOGLUTATHIONE

S-NITROSOGLUTATHIONE
  • CAS No.:57564-91-7
Other grades of this product :
S-NITROSOGLUTATHIONE Basic information
Product Name:S-NITROSOGLUTATHIONE
Synonyms:L-γ-GlutaMyl-S-nitroso-L-cysteinyl-glycine;RVC 588;N-(N-L-gama-glutamyl-S-nitroso-L-cysteinyl)glycine;RVC 588 (peptide);S-Nitrosylglutathione;(S)-2-aMino-5-(((R)-1-((carboxyMethyl)aMino)-3-(nitrosothio)-1-oxopropan-2-yl)aMino)-5-oxopentanoic acid;nitrosoglutathione(GSNO);L-γGlu-S-Nitroso-L-Cys-Gly-OH
CAS:57564-91-7
MF:C10H16N4O7S
MW:336.32
EINECS:637-341-5
Product Categories:Peptides;Sulfur & Selenium Compounds;Nitric Oxide Reagents;Nitric Oxide;Signalling
Mol File:57564-91-7.mol
S-NITROSOGLUTATHIONE Chemical Properties
Melting point >170°C (dec.)
density 1.68
refractive index 1.6000 (estimate)
storage temp. -20°C
solubility DMSO (Slightly), Water (Slightly)
form Pink solid
pka2.21±0.10(Predicted)
color Off-White to Pink
Stability:Hygroscopic
CAS DataBase Reference57564-91-7(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 3
RTECS MC0558000
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
S-NITROSOGLUTATHIONE Usage And Synthesis
DescriptionS-Nitroso-L-glutathione is an S-nitrosothiol NO donor based on naturally-occurring glutathione. It is a potent smooth muscle relaxant and inhibitor of platelet aggregation. Its stability in solution varies from seconds to hours depending on temperature, buffer composition, and metal content.
Chemical PropertiesPink Powder
UsesA carrier of nitric oxide, relaxing smooth muscle and inhibiting platelet activation
UsesS-Nitrosoglutathione (GSNO) has been used:
  • as a standard in reversed phase chromatography coupled to chemical vapour generation and atomic fluorescence detector (RPC-CVGAFS) and reversed phase chromatography fluorimetric (RPC-FD).
  • as a standard in spectrophotometric and high-performance liquid chromatography (HPLC) assay.
General DescriptionA utility carrier of nitric oxide. Breaks down at physiological pH to produce nitric oxide. Causes smooth muscle relaxation and inhibits platelet aggregation. Induces apoptosis in mouse thymocytes. Note: 1 set = 5 x 2.5 mg.
Biological ActivityA carrier of NO, relaxing smooth muscle and inhibiting platelet aggregation.
Biochem/physiol ActionsProduct does not compete with ATP.

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