HARRINGTONINE

CAS No.：26833-85-2

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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HARRINGTONINE Basic information

Product Name:	HARRINGTONINE
Synonyms:	(3(r))-ter;4-methyl-cephalotaxin2-hydroxy-2-(3-hydroxy-3-methylbutyl)butanedioate(es;alkaloidcfromcephalotaxus;cephalotaxine,4-methyl(2r)-2-hydroxy-2-(3-hydroxy-3-methylbutyl)butanedioat;nsc124147;HARRINGTONIN;HARRINGTONINE;HT
CAS:	26833-85-2
MF:	C28H37NO9
MW:	531.6
EINECS:
Product Categories:	Intermediates & Fine Chemicals;Pharmaceuticals;Alkaloids
Mol File:	26833-85-2.mol

HARRINGTONINE Chemical Properties

Melting point	73～75℃
Boiling point	679.4±55.0 °C(Predicted)
density	1.35±0.1 g/cm3(Predicted)
storage temp.	2-8°C
pka	11.62±0.29(Predicted)

Safety Information

RIDADR	1544
HazardClass	6.1(a)
PackingGroup	II

MSDS Information

HARRINGTONINE Usage And Synthesis

Description	The full structure of harringtonine has now been established from a study of the hydrolysis products of this base.
Description	Harringtonine is a natural alkaloid that inhibits protein synthesis at low micromolar concentrations. It immobilizes ribosomes immediately after the initiation of translation. While harringtonine has drawn some interest in mitigating cancer, its homolog homoharrington is more effective, particularly for chronic myelogenous leukemia. The ability of harringtonine to immobilize initiating ribosomes can be used to capture ribosome-protected mRNA fragments for evaluating translation.
Chemical Properties	White Solid
Uses	specific anti-leukemia drug
Uses	A natural product with significant antitumor activities.
References	Mikolajczak, Powell, Smith, Tetrahedron, 28, 1995 (1972) Kelly, McKenna, Christenson, Tetrahedron Lett., 35m (1973)

HARRINGTONINE Preparation Products And Raw materials

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