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| 4-Acetylbenzoic acid Basic information | | Uses |
| 4-Acetylbenzoic acid Chemical Properties |
| Melting point | 208-210 °C(lit.) | | Boiling point | 251.61°C (rough estimate) | | density | 1.2132 (rough estimate) | | refractive index | 1.5380 (estimate) | | storage temp. | Sealed in dry,Room Temperature | | solubility | DMSO (Slightly), Methanol (Slightly) | | pka | pK1: 3.70 (25°C) | | form | Crystals or Crystalline Powder | | color | White | | Water Solubility | soluble | | BRN | 2207355 | | InChIKey | QBHDSQZASIBAAI-UHFFFAOYSA-N | | CAS DataBase Reference | 586-89-0(CAS DataBase Reference) | | NIST Chemistry Reference | 4-Acetylbenzoic acid(586-89-0) |
| 4-Acetylbenzoic acid Usage And Synthesis |
| Uses | 4-Acetylbenzoic Acid is an intermediate used to prepare Curcumin Analogs with anti-oxidant activities. It is also used in the synthesis of quinuclidine benzamides as agonists of α7 nicotinic acetylcholine receptors. | | Chemical Properties | White to light yellow crystal powder | | Uses | 4-Acetylbenzoic acid was used in the preparation of an ester-derivative of paclitaxel. | | Synthesis Reference(s) | Synthesis, p. 715, 1974 DOI: 10.1055/s-1974-23412 | | Purification Methods | 4-AcDissolve the acid in 5% aqueous NaOH, extract it with Et2O, and acidify the aqueous solution. Collect the precipitate, and recrystallise it from boiling H2O (100 parts) using decolorising charcoal [Pearson et al. J Org Chem 24 504 1959, Pearson et al. J Chem Soc 265 1957, Detweiler & Amstutz J Am Chem Soc 72 2882 1950, Bordwell & Cooper J Am Chem Soc 74 1058 1952]. [Beilstein 10 IV 2769.] |
| 4-Acetylbenzoic acid Preparation Products And Raw materials |
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