| 4-CHLORO-7-FLUORO-6-NITRO-QUINAZOLINE Basic information |
| Product Name: | 4-CHLORO-7-FLUORO-6-NITRO-QUINAZOLINE |
| Synonyms: | 4-CHLORO-7-FLUORO-6-NITRO-QUINAZOLINE;4-CHLORO-7-FLUORO-6-NITRO-QUINAZOLINE###162012-70-6;4-chloro-6-nitro-7-fluoro-quinazoline;Afatinib impurity 6: 4-chloro-7fluoro-6-nitroquinazoline;Quinazoline, 4-chloro-7-fluoro-6-nitro-;162012-70-6 |
| CAS: | 162012-70-6 |
| MF: | C8H3ClFN3O2 |
| MW: | 227.58 |
| EINECS: | |
| Product Categories: | |
| Mol File: | 162012-70-6.mol |
| 4-CHLORO-7-FLUORO-6-NITRO-QUINAZOLINE Chemical Properties |
| Boiling point | 395℃ |
| density | 1.649 |
| Fp | 193℃ |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| pka | 0.53±0.70(Predicted) |
| Safety Information |
| Hazard Codes | Xn |
| Risk Statements | 22-36 |
| Safety Statements | 26 |
| MSDS Information |
| 4-CHLORO-7-FLUORO-6-NITRO-QUINAZOLINE Usage And Synthesis |
| Uses | 4-Chloro-7-fluoro-6-nitroquinazoline is an intermediate in the synthesis of Afatinib (A355300), an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder. |
| 4-CHLORO-7-FLUORO-6-NITRO-QUINAZOLINE Preparation Products And Raw materials |
| Preparation Products | N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-aminoquinazolin-4-aMine |
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