| Chemical Properties | white to light yellow crystal powde |
| Uses | Isosorbide 5-Mononitrate is a metabolite of Isosorbide Dinitrate; used as an antianginal. |
| Uses | antidepressant, 5HT reuptake inhibitor |
| Uses | A metabolite of Isosorbide Dinitrate. Used as an antianginal |
| Brand name | Imdur (Schering-Plough); Ismo (Dr. Reddy’s);
Monoket (Schwarz Pharma)
. |
| General Description | Isosorbide 5-mononitrate is a crystalline solid. Isosorbide 5-mononitrate is very flammable and may be toxic by ingestion. |
| Air & Water Reactions | Highly flammable. |
| Reactivity Profile | The dinitrate, a heart drug, can detonate when dry, but is non explosive with 30% of water [J. Haz.. Mater., 1992, 32(1), 87]. The mononitrate would be expected to be less reactive. |
| Health Hazard | Fire may produce irritating and/or toxic gases. Contact may cause burns to skin and eyes. Contact with molten substance may cause severe burns to skin and eyes. Runoff from fire control may cause pollution. |
| Fire Hazard | Flammable/combustible material. May be ignited by friction, heat, sparks or flames. Some may burn rapidly with flare burning effect. Powders, dusts, shavings, borings, turnings or cuttings may explode or burn with explosive violence. Substance may be transported in a molten form at a temperature that may be above its flash point. May re-ignite after fire is extinguished. |
| Clinical Use | Vasodilator:
Treatment and prophylaxis of angina
Adjunct in congestive heart failure |
| Drug interactions | Potentially hazardous interactions with other drugs
Avanafil: hypotensive effect significantly enhanced -
avoid.
Levosimendan: possible severe hypotension.
Riociguat: avoid concomitant use due to risk of
hypotension.
Sildenafil: hypotensive effect significantly enhanced
- avoid.
Tadalafil: hypotensive effect significantly enhanced
- avoid.
Vardenafil: hypotensive effect significantly enhanced
- avoid. |
| Metabolism | Unlike isosorbide dinitrate, isosorbide mononitrate does
not undergo first-pass hepatic metabolism. Isosorbide
mononitrate is taken up by smooth muscle cells of blood
vessels and the nitrate group is cleaved to inorganic
nitrite and then to nitric oxide. Isosorbide mononitrate is
metabolised to inactive metabolites, including isosorbide
and isosorbide glucuronide |
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