Benz[cd]indol-2(1H)-one

CAS No.：130-00-7

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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Benz[cd]indol-2(1H)-one Basic information

Product Name:	Benz[cd]indol-2(1H)-one
Synonyms:	BENZO[CD]INDOL-2(1H)-ONE;BENZ[CD]INDOL-2(1H)-ONE;2(1h)-perinaphthazolone;naphtholactam;1,8-Naphthaolactam;Naphthostyril 1,8-Naphtholactam;1,8-Naphthostyril;2H-benzo[f]indol-2-one
CAS:	130-00-7
MF:	C11H7NO
MW:	169.18
EINECS:	204-973-4
Product Categories:	Building Blocks;C11;Fused Ring Systems;Building Blocks;Chemical Synthesis;Heterocyclic Building Blocks;Intermediates of Dyes and Pigments;Heterocyclic Building Blocks;Indoles
Mol File:	130-00-7.mol

Benz[cd]indol-2(1H)-one Chemical Properties

Melting point	173-178 °C(lit.)
Boiling point	298.46°C (rough estimate)
density	1.1616 (rough estimate)
vapor pressure	0.61-7.2Pa at 100-130℃
refractive index	1.4900 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	methanol: soluble25mg/mL, clear to slightly hazy, yellow to brown
pka	13.27±0.20(Predicted)
form	Powder
color	Light orange to Yellow to Green
InChIKey	GPYLCFQEKPUWLD-UHFFFAOYSA-N
LogP	2.5 at 24℃ and pH6.6
CAS DataBase Reference	130-00-7(CAS DataBase Reference)
EPA Substance Registry System	Benz[cd]indol-2(1H)-one (130-00-7)

Safety Information

Hazard Codes	Xn
Risk Statements	22
Safety Statements	24/25
WGK Germany	2
RTECS	DE3202000
HS Code	29337900

MSDS Information

Provider	Language
SigmaAldrich	English

Benz[cd]indol-2(1H)-one Usage And Synthesis

Uses	• ;Reactant in photo-Fries rearrangement1• ;Reactant in preparation of potential antitumor agents2• ;Reactant in synthesis of inhibitors of thymidylate synthase3
Uses	Benz[cd]indol-2(1H)-one was used in the synthesis of 2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamide analog, novel Mycobacterium protein tyrosine phosphatase B (mPTPB) inhibitor.
General Description	Benz[cd]indol-2(1H)-one is also referred as naphtholactam.

Benz[cd]indol-2(1H)-one Preparation Products And Raw materials

Raw materials	Potassium hydroxide-->Sodium bisulfite-->Sodium hypochlorite-->1,8-Naphthalimide
Preparation Products	dibenzo[def,mno]chrysene-6,12-dione-->Solvent Yellow 98-->Disperse Red 196

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