Product

N-EPSILON-ACETYL-L-LYSINE

CAS No.：692-04-6

Other grades of this product :

N-EPSILON-ACETYL-L-LYSINE Basic information

Product Name:	N-EPSILON-ACETYL-L-LYSINE
Synonyms:	N-E-ACETYL-L-LYSINE;N-EPSILON-ACETYL-L-LYS;N-EPSILON-ACETYL-L-LYSINE;H-LYS(AC)-OH;H-L-LYS(AC)-OH;(2S)-6-acetamido-2-amino-hexanoic acid;N-epsilon-acetyllysine;LYSINE(AC)-OH
CAS:	692-04-6
MF:	C8H16N2O3
MW:	188.22
EINECS:	211-725-9
Product Categories:	A - H;Amino Acids;Modified Amino Acids
Mol File:	692-04-6.mol

N-EPSILON-ACETYL-L-LYSINE Chemical Properties

Melting point	250 °C (dec.)(lit.)
Boiling point	323.23°C (rough estimate)
density	1.1793 (rough estimate)
refractive index	1.4500 (estimate)
storage temp.	-20°C
solubility	Aqueous Base (Slightly), Water (Slightly)
form	Powder
pka	2.53±0.24(Predicted)
color	White
Water Solubility	Soluble in water (miscible), and 80% acetic acid (50 mg/ml).
Sensitive	Hygroscopic
InChIKey	DTERQYGMUDWYAZ-ZETCQYMHSA-N
CAS DataBase Reference	692-04-6(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	24/25-36-26
WGK Germany	3
HS Code	29241900

MSDS Information

Provider	Language
ACROS	English
SigmaAldrich	English

N-EPSILON-ACETYL-L-LYSINE Usage And Synthesis

Description	Acetyllysine (or acetylated lysine) is an acetyl-derivative of the amino acid lysine. There are multiple forms of acetyllysine - this article refers to N-ε-acetyl-L-lysine. The other form is N-α-acetyl-Llysine. In proteins, the acetylation of lysine residues is an important mechanism of epigenetics. It functions by regulating the binding of histones to DNA in nucleosomes and thereby controlling the expression of genes on that DNA. Non-histone proteins are acetylated as well. Unlike the functionally similar methyllysine, acetyllysine does not carry a positive charge on its side chain. Histone acetyltransferases (HATs) catalyze the addition of acetyl groups from acetyl-CoA onto certain lysine residues of histones and non-histone proteins. Histone deacetylases (HDACs) catalyze the removal of acetyl groups from acetylated lysines. Acetyllysine can be synthesized from lysine by the selective acetylation of the terminal amine group.
Chemical Properties	white crystalline powder
Uses	N-Epsilon-acetyl-l-lysine is used in the metabolomics study on the combined effect of cocaine and ethanol via liquid chromatography-mass spectrometry metabolomics approach.
Definition	ChEBI: An N6-acyl-L-lysine where the N6-acyl group is specified as acetyl.
Biochem/physiol Actions	Nε-Acetyl-L-lysine (L-AcK) is an R-chain N-acetylated α amino acid used together with other lysine analogues to differentiate and characterized various aminoacylases and regulator 2 (Sir2) enzymes/sirtuins.

N-EPSILON-ACETYL-L-LYSINE Preparation Products And Raw materials

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