4-(Trifluoromethoxy)aniline

4-(Trifluoromethoxy)aniline
  • CAS No.:461-82-5
Other grades of this product :
4-(Trifluoromethoxy)aniline Basic information
Product Name:4-(Trifluoromethoxy)aniline
Synonyms:Riluzole Related Compound A (25 mg) (4-trifluoromethoxyaniline);4-(TrifluoroMethoxy)aniline, 99+% 2.5GR;Riluzole Related CoMpound A;For trifluoromethoxy aniline;4- threedifluoro Methoxyaniline;4-TrifluoroMethoxyaniline, 97+%;The trifluoro Methoxy aniline;4-(TrifluoroMe
CAS:461-82-5
MF:C7H6F3NO
MW:177.12
EINECS:207-317-5
Product Categories:Building Blocks;C7;Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks;Pyridines;Trifluoroanisole series;Trifluoromethoxybenzene Series;Anilines, Aromatic Amines and Nitro Compounds;Amines;Phenyls & Phenyl-Het;Phenyls & Phenyl-Het;Pharmaceutical Intermediate;amine
Mol File:461-82-5.mol
4-(Trifluoromethoxy)aniline Chemical Properties
Boiling point 73-75 °C10 mm Hg(lit.)
density 1.32 g/mL at 20 °C(lit.)
refractive index n20/D 1.463(lit.)
Fp 177 °F
storage temp. Keep in dark place,Inert atmosphere,Room temperature
form Liquid
pka3.75±0.10(Predicted)
Specific Gravity1.310
color Clear colorless to yellow
BRN 2090209
InChIKeyXUJFOSLZQITUOI-UHFFFAOYSA-N
CAS DataBase Reference461-82-5(CAS DataBase Reference)
Safety Information
Hazard Codes T,Xi,Xn
Risk Statements 24/25-33-38-41-36/37/38-20/21/22
Safety Statements 26-36/37/39-45-36
RIDADR UN 2941 6.1/PG 3
WGK Germany 2
Hazard Note Toxic
HazardClass IRRITANT, TOXIC
HazardClass 6.1
PackingGroup III
HS Code 29222900
MSDS Information
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4-(Trifluoromethoxy)aniline English
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4-(Trifluoromethoxy)aniline Usage And Synthesis
Chemical PropertiesCLEAR YELLOW LIQUID
Uses4-(Trifluoromethoxy)aniline was used in the synthesis of:
  • side-group liquid-crystalline polymethacrylates with fluorine-containing mesogens
  • derivatives of 3-(quinolin-3-yl)acrylates
  • series of novel Shiff bases, via condensation with pyridinecarboxaldehydes in the presence of molecular sieves
Uses4-(Trifluoromethoxy)aniline is used in the synthesis of anticancer agents and antitumor medicaments. Also, its an intermediate in the production of labelled Riluzole, a neuroprotective agent. Modulates glutamatergic transmission. A glutamate release inhibitor. An anticonvulsant.

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