Boc-6-AMinocaproic acid

CAS No.：6404-29-1

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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Boc-6-AMinocaproic acid Basic information

Product Name:	Boc-6-AMinocaproic acid
Synonyms:	Boc-6-Ahx-OH ,98.5%(HPLC);Boc-6-Ahx-OH,6-(Boc-amino)caproic acid, 6-(Boc-amino)hexanoic acid, Boc-6-aminohexanoic acid;Boc-6-Ahx-OH(Boc-6-aMinohexanoic acid);Boc-ε- AMinocaproic acid Boc-ε- AMinocaproic acid;6-[N-(tert-Butoxycarbonyl)aMino]caproic Acid;N-(tert-Butoxycarbonyl)-ε-aMinocaproic Acid;N-(tert-Butoxycarbonyl)-ε-aMinohexanoic Acid;N-(tert-Butyloxycarbonyl)-ε-aMinocaproic Acid
CAS:	6404-29-1
MF:	C11H21NO4
MW:	231.29
EINECS:
Product Categories:	Amino Acid Derivatives;Aliphatics;Amino Acids;Unusual Amino Acids;Amines
Mol File:	6404-29-1.mol

Boc-6-AMinocaproic acid Chemical Properties

Melting point	35-40 °C
Boiling point	166°C/0.3mmHg(lit.)
density	1.065±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	Chloroform, Ethyl Acetate
pka	4.76±0.10(Predicted)
form	Powder
color	White
Water Solubility	Soluble in chloroform and ethyl acetate. Slightly soluble in water.
BRN	2049561
CAS DataBase Reference	6404-29-1(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	22-24/25-26
WGK Germany	3
F	21
HazardClass	IRRITANT
HS Code	29241990

MSDS Information

Provider	Language
SigmaAldrich	English

Boc-6-AMinocaproic acid Usage And Synthesis

Description	Boc-6-aminohexanoic acid is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
Chemical Properties	Colorless crystal
Uses	6-(Boc-amino)hexanoic acid is used in the preparation of esters of 6-aminohexanoic acid as antibacterial agents. EACA is reported to inhibit chymotrypsin, Factor VIIa, lysine carboxy peptidase, plasmin, and plasminogen activator.
Uses	Protected ε-Aminocaproic Acid (A603015), Boc-6-AMinocaproic acid can be used in the preparatiom of esters of 6-aminohexanoic acid.

Boc-6-AMinocaproic acid Preparation Products And Raw materials

Preparation Products

N-BOC-1,6-diaminohexane-->1,8-diazacyclotetradecane-2,9-dione-->METHYL 6-AMINOCAPROATE HYDROCHLORIDE-->6-(BOC-AMINO)-HEXYL BROMIDE

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