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| Ceftriaxone sodium Basic information |
| Product Name: | Ceftriaxone sodium | | Synonyms: | (6R,7R)-7-[[(2Z)-2-(2-AMino-4-thiazolyl)-2-(MethoxyiMino)acetyl]aMino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-Methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]Methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid SodiuM Salt Hydrate;Ceftriaxone sodiuM sesquaterhydrate;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-, sodium salt, hydrate (2:4:7), (6R,7R)-;Ceftriaxone SodiuM Trihydrate;Ceftriaxone disodium salt hemiheptahydrate, >=98%;sodium 7-[[2-(2-amino-4-thiazolyl)-2-methoxyimino-1-oxoethyl]amino]-3-[[(2-methyl-5,6-dioxo-1H-1,2,4-triazin-3-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-, sodium salt, hydrate (2:;Ceftriaxone (sodium salt hydrate) | | CAS: | 104376-79-6 | | MF: | C18H16N8Na2O7S3.31/2H2O | | MW: | 598.54 | | EINECS: | 626-956-4 | | Product Categories: | VESPRIN;Antibiotics for Research and Experimental Use;API;beta-Lactams (Antibiotics for Research and Experimental Use);Biochemistry;Antibiotic Explorer;Intermediates & Fine Chemicals;Pharmaceuticals;A - KAntibiotics;Antibacterial;Antibiotics A to;Antibiotics A-FAntibiotics;Chemical Structure Class;Interferes with Cell Wall SynthesisAntibiotics;Mechanism of Action;Penicillins and Cephalosporins (beta-Lactams);Spectrum of Activity;Ceftriaxone;Heterocycles;Sulfur & Selenium Compounds | | Mol File: | 104376-79-6.mol |
| Ceftriaxone sodium Chemical Properties |
| Melting point | 236 °C | | alpha | D25 -165° (c = 1 in water) (calc for water-free substance) | | refractive index | -160 ° (C=1, H2O) | | storage temp. | Keep in dark place,Inert atmosphere,2-8°C | | solubility | H2O: soluble50mg/mL | | pka | ~3 (COOH), 3.2 (NH3+), 4.1 (enolic OH) | | form | powder or crystals | | color | White to Off-White | | Water Solubility | Freely soluble in water | | InChIKey | FDRNWTJTHBSPMW-BBJOQENWSA-L |
| Hazard Codes | Xn | | Risk Statements | 36/37/38-42/43 | | Safety Statements | 26-36-45-37-24-22 | | WGK Germany | 1 | | RTECS | XI0368800 | | HS Code | 29349990 | | Toxicity | LD50 in male, female, mice, rats (mg/kg): 3000, 2800, 2175, 2175 i.v.; >10000 all species orally; >5000 all species s.c. (Teelman) |
| Ceftriaxone sodium Usage And Synthesis |
| Description | Ceftriaxone is a third-generation, broad-spectrum cephalosporin antibiotic that disrupts the synthesis of the peptidoglycan layer of bacterial cell walls. It has been shown to increase excitatory amino acid transporter-2 pump expression in the central nervous system and to reduce glutamatergic toxicity in both in vitro and in vivo models. | | Chemical Properties | White Crystalline Solid | | Uses | antipsychotic | | Uses | An antibacterial, a third-generation cephalosporin. | | Uses | A potentially useful antibacterial agent for proteomics research. | | Brand name | Rocephin (Roche). | | Biological Activity | β -lactam antibiotic. Displays neuroprotective activity in vivo via upregulation and increased activity of the EAAT2 glutamate transporter. |
| Ceftriaxone sodium Preparation Products And Raw materials |
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