5-Fluoro-2-oxindole

CAS No.：56341-41-4

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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5-Fluoro-2-oxindole Basic information

Product Name:	5-Fluoro-2-oxindole
Synonyms:	5-Fluoroindole-2-One;5-Fluoro-1,3-dihydro-indol-2-one;5-FLUORO-2-OXINDOLE;5-FLUORO-2-OXYINDOLE;5-FLUORO-1,3-DIHYDRO-2H-INDOL-2-ONE;5-Fluorooxindole 98%;5-Fluorooxindole98%;5-FLUROOXINDOLE
CAS:	56341-41-4
MF:	C8H6FNO
MW:	151.14
EINECS:	638-803-9
Product Categories:	Fluorinated heterocyclic series;Indoles and derivatives;Indole/indoline/oxindole;Indole and Indoline;Heterocycles;Aromatics Compounds;Halides;Pyrroles & Indoles;ketone;Sunitinib;Intermediate of sunitinib malate;Aromatics;Pyrroles & Indoles;Boronic Acid;INDOLE;blocks;FluoroCompounds;IndolesOxindoles;Heterocyclic Compounds;Building Blocks;Heterocyclic Building Blocks;Indoles;Intermediates;56341-41-4
Mol File:	56341-41-4.mol

5-Fluoro-2-oxindole Chemical Properties

Melting point	143-147 °C (lit.)
Boiling point	307.2±42.0 °C(Predicted)
density	1.311±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
pka	12.99±0.20(Predicted)
form	Powder or Crystalline Powder
color	White to pale brown
InChIKey	DDIIYGHHUMKDGI-UHFFFAOYSA-N
CAS DataBase Reference	56341-41-4(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi,C
Risk Statements	36/37/38-34
Safety Statements	22-24/25-45-36/37/39-27-26
WGK Germany	3
Hazard Note	Irritant/Keep Cold
HazardClass	IRRITANT, KEEP COLD
HS Code	29339900

MSDS Information

Provider	Language
SigmaAldrich	English

5-Fluoro-2-oxindole Usage And Synthesis

Chemical Properties	Light Yellow Crystalline
Uses	5-Fluoro-2-oxindole (cas# 56341-41-4) is a compound useful in organic synthesis.
Application	5-Fluoro-2-oxindole is a ketone organic compound that can be used as an intermediate in the preparation of sunitinib. Sunitinib is a novel multi-targeted oral drug for the treatment of tumors.
Preparation	synthesis of 5-fluoro-2-oxindole: 4-fluoroaniline was used as the starting material, reacted with chloral hydrate and hydroxylamine hydrochloride to generate 4-fluoroisonitrosoacetanilide, and then cyclized under the action of concentrated sulfuric acid to form the compound 5-fluoroisatin was finally obtained by wolff-kishner-huang minlon reduction to obtain 5-fluoro-2-oxindole with a total yield of 66%.

5-Fluoro-2-oxindole Preparation Products And Raw materials

Raw materials

Sodium hydride-->Iron-->Dimethyl sulfoxide-->Dimethyl malonate-->Lithium chloride-->2,4-Difluoronitrobenzene-->1-hydroxy-3H-indol-2-one-->Ethyl iodoacetate-->4-FLUOROISONITROSOACETANILIDE-->5-Fluoro-3-hydrazonoindolin-2-one-->2-(2-aMino-5-fluorophenyl)acetohydrazide-->5-Fluoro-2-nitrophenylacetic acid-->Benzeneacetic acid, 5-fluoro-2-nitro-, Methyl ester-->5-Fluoroisatin-->4-Fluoroacetanilide-->ETHYL (METHYLTHIO)ACETATE-->tert-Butyl Hypochlorite

Preparation Products

Toceranib

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