| Methyl 4-hydroxycinnamate Basic information |
| Product Name: | Methyl 4-hydroxycinnamate |
| Synonyms: | METHYL 3-(4-HYDROXYPHENYL)ACRYLATE;METHYL P-HYDROXYCINNAMATE;METHYL 4-COUMARATE;3-(4-hydroxyphenyl)prop-2-enoic acid methyl ester;methyl (2Z)-3-(4-hydroxyphenyl)acrylate;methyl (E)-3-(4-hydroxyphenyl)prop-2-enoate;Methyl 4-hydroxycinnamate, >=98.5%;(E)-3-(4-hydroxyphenyl)-2-methyl-2-propenoate |
| CAS: | 3943-97-3 |
| MF: | C10H10O3 |
| MW: | 178.18 |
| EINECS: | 223-531-1 |
| Product Categories: | Aromatic Esters;Aromatic Cinnamic Acids, Esters and Derivatives;Inhibitors |
| Mol File: | 3943-97-3.mol |
| Methyl 4-hydroxycinnamate Chemical Properties |
| Melting point | 144-145° |
| Boiling point | 306.6±17.0 °C(Predicted) |
| density | 1?+-.0.06 g/cm3(Predicted) |
| vapor pressure | 0.056Pa at 25℃ |
| storage temp. | Inert atmosphere,Room Temperature |
| pka | 8.82±0.13(Predicted) |
| Water Solubility | 5.332g/L at 25℃ |
| LogP | 1.88 at 25℃ |
| CAS DataBase Reference | 3943-97-3(CAS DataBase Reference) |
| NIST Chemistry Reference | 2-Propenoic acid, 3-(4-hydroxyphenyl)-, methyl ester(3943-97-3) |
| Safety Information |
| HazardClass | IRRITANT |
| HS Code | 2916399090 |
| MSDS Information |
| Methyl 4-hydroxycinnamate Usage And Synthesis |
| Description | Methyl 4-hydroxycinnamate is an atifungal agent and a cinnamic acid derivative used in structure-antifungal activity relationship studies against Aspergillus flavus, Aspergillus terreus, and Aspergillus niger. |
| Occurrence | Methyl 4-hydroxycinnamate isolated from the herbs of Piper longum, Alpinia blepharocalyx, and Grevillea robusta. |
| Uses | 3-(4-Hydroxyphenyl)-2-propenoic Acid Methyl Ester is used in the synthesis of AB3 and constitutional isomeric AB2 phenylpropyl ether-based supramolecular dendrimers. Also used in the synthesis of potent antagonists of leukotrines. |
| Definition | ChEBI: 4-coumaric acid methyl ester is a cinnamate ester that is the methyl ester of 4-coumaric acid. It has a role as a melanin synthesis inhibitor, a fungal metabolite, an anti-inflammatory agent, an antifungal agent and a plant metabolite. It is a cinnamate ester, a member of phenols and a methyl ester. It derives from a 4-coumaric acid. |
| Synthesis Reference(s) | Chemical and Pharmaceutical Bulletin, 28, p. 3662, 1980 DOI: 10.1248/cpb.28.3662 |
| Methyl 4-hydroxycinnamate Preparation Products And Raw materials |
| Raw materials | 4-Hydroxycinnamic acid-->methyl (triphenylphosphoranylidene)acetate-->Methanol-->4-Bromophenol-->4-Hydroxybenzaldehyde-->4-Iodophenol-->acrylic acid methyl ester |
| Preparation Products | Methyl 3-(4-hydroxyphenyl)propionate |
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