| 3-Bromoquinoline Basic information |
| Bromoquinoline Application and synthesis method Uses |
| Product Name: | 3-Bromoquinoline |
| Synonyms: | 3-bromo-quinolin;3-BROMOQUINLIINE;3-BROMOQUINOLINE;Bromoquinoline;Quinoline, 3-bromo-;3-Bromoquinoline98%Or99%;3-Bromoquinoline 98 %;3-Bromoquinoline ,98% [HPLC 98%] |
| CAS: | 5332-24-1 |
| MF: | C9H6BrN |
| MW: | 208.05 |
| EINECS: | 226-237-1 |
| Product Categories: | Aromatics Compounds;Haloquinolines;Quinoline&Isoquinoline;Quinoline Derivertives;Aromatics;Building Blocks;blocks;Bromides;Halides;Heterocycles;Quinolines, Quinazolines and derivatives;Halogenated Heterocycles;Heterocyclic Building Blocks;QuinolinesHeterocyclic Building Blocks;Quinolines |
| Mol File: | 5332-24-1.mol |
| 3-Bromoquinoline Chemical Properties |
| Melting point | 13-15 °C (lit.) |
| Boiling point | 274-276 °C (lit.) |
| density | 1.533 g/mL at 25 °C (lit.) |
| vapor pressure | 0.196Pa at 25℃ |
| refractive index | n |
| Fp | >230 °F |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| pka | 2.69(at 25℃) |
| form | Liquid |
| color | Clear colorless to yellow |
| Water Solubility | 103mg/L at 25℃ |
| BRN | 112939 |
| InChIKey | ZGIKWINFUGEQEO-UHFFFAOYSA-N |
| LogP | 3.03 |
| CAS DataBase Reference | 5332-24-1(CAS DataBase Reference) |
| NIST Chemistry Reference | Quinoline, 3-bromo-(5332-24-1) |
| EPA Substance Registry System | Quinoline, 3-bromo- (5332-24-1) |
| Safety Information |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36-37/39 |
| RIDADR | UN2810 |
| WGK Germany | 3 |
| TSCA | Yes |
| HS Code | 29334900 |
| MSDS Information |
| Provider | Language |
|---|---|
| 3-Bromoquinoline | English |
| ACROS | English |
| SigmaAldrich | English |
| ALFA | English |
| 3-Bromoquinoline Usage And Synthesis |
| Bromoquinoline | There are seven position isomers with the main properties are as follows:
▼ ▲ Name
Melting point(℃)
Boiling point(℃)
Solubility
2-bromoquinoline
48～49
It is soluble in diethyl ether, chloroform and benzene
3-bromoquinoline
12～15
274～276,
95(66.66Pa)
4-bromoquinoline
29～30
270(decomposition)
Easily soluble in dilute acid
5-bromoquinoline
52 (needle crystal)
280
6-bromoquinoline
24
278
7-bromoquinoline
52 (needle crystal)
290
8-bromoquinoline
80
165～166
(2399.79Pa)
|
| Application and synthesis method | 3-Bromoquinoline can have action with mixed acid to generate 3-bromo-5-nitroquinoline, followed by heating with potassium permanganate to be oxidized to 5-bromo-2, 3-pyridine dicarboxylic acid. 6-bromo-quinoline can be heated together nitric acid to generate 6-bromo-8-nitro-quinoline, followed by reaction with potassium permanganate to be oxidized into 2, 3-pyridinedicarboxylic acid. 2-bromo-quinoline can be manufactured through the reaction between 2-hydroxyquinoline and phosphorus pentabromide 3-bromo-quinoline can be obtained through heating the quinoline perbromide at 180 ° C. 4-bromoquinoline can be obtained through either the heating reaction between 4-hydroxyquinoline and phosphorus pentabromide or by the diazotization reaction of 4-aminoquinoline. 5-bromo-quinoline can be obtained from the heating reaction between m-bromo aniline, glycerol, m-bromonitrobenzene and concentrated sulfuric acid, or through the diazotization reaction of 5-amino-quinoline. 6-bromo-quinoline can be obtained through the heating reaction between p-bromoaniline, glycerol, concentrated sulfuric acid and p-bromo-nitrobenzene. 7-bromoquinoline can be obtained through the diazotization of 7-aminoquinoline. 8-bromo-quinoline can be obtained through the heating of o-bromo aniline, glycerol, concentrated sulfuric acid and o-bromo-nitrobenzene in the heating system. Purposes: as organic synthesis reagents. |
| Uses | For pharmaceuticals Medicine, pesticide intermediates |
| Chemical Properties | colorless to light yellow liquid |
| Synthesis Reference(s) | The Journal of Organic Chemistry, 27, p. 1318, 1962 DOI: 10.1021/jo01051a047 |
| General Description | 3-Bromoquinoline undergoes bromine-magnesium exchange reaction with lithium tributylmagnesate in toluene at -10°C, which is quenched by various electrophiles to yield functionalized quinolines. |
| Flammability and Explosibility | Notclassified |
| 3-Bromoquinoline Preparation Products And Raw materials |
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