Product

1-METHYL-4-[5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABORALAN-2-YL)PYRIDINE-2-YL]PIPERAZINE

CAS No.：918524-63-7

Other grades of this product :

1-METHYL-4-[5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABORALAN-2-YL)PYRIDINE-2-YL]PIPERAZINE Basic information

Product Name:	1-METHYL-4-[5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABORALAN-2-YL)PYRIDINE-2-YL]PIPERAZINE
Synonyms:	1-METHYL-4-[5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABORALAN-2-YL)PYRIDINE-2-YL]PIPERAZINE;1-methyl-4-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)piperazine HCl;2-(4-Methylpiperazino)pyridine-5-boronic acid pinacol ester;1-Methyl-4-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]piperazine, 2-(4-Methylpiperazin-1-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine;Piperazine, 1-Methyl-4-[5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]-;6-(4-Methylpiperazin-1-yl)pyridin-3-ylboronic acid pinacol ester;6-(4-Methyl-1-piperazinyl)pyridine-3-boronic Acid Pinacol Ester;2-(4-Methylpiperazino)pyridine-5-boronic acid pinacol ester 2-(4-Methylpiperazin-1-yl)pyridine-5-boronic acid pinacol ester
CAS:	918524-63-7
MF:	C16H26BN3O2
MW:	303.21
EINECS:
Product Categories:
Mol File:	918524-63-7.mol

1-METHYL-4-[5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABORALAN-2-YL)PYRIDINE-2-YL]PIPERAZINE Chemical Properties

Melting point	125 °C
Boiling point	435.2±45.0 °C(Predicted)
density	1.10±0.1 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
pka	8.41±0.31(Predicted)
form	solid
color	white

Safety Information

Hazard Codes	C
Risk Statements	22-34
Safety Statements	22-26-36/37/39-45
TSCA	No
HS Code	2933998090

MSDS Information

1-METHYL-4-[5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABORALAN-2-YL)PYRIDINE-2-YL]PIPERAZINE Usage And Synthesis

Uses	1-Methyl-4-[5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridin-2-yl]piperazine is used to prepare yrazolopyridine and indazoles as histone lysine methyltransferase EZH2 inhibitors. It is also used to synthesize tetrahydropyrido pyrazines as anaplastic lymphoma kinase inhibitors.

1-METHYL-4-[5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABORALAN-2-YL)PYRIDINE-2-YL]PIPERAZINE Preparation Products And Raw materials

Raw materials

5-Bromo-2-(4-Boc-piperazin-1-yl)pyridine-->2,5-Dibromopyridine-->2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane-->1,4-Dioxane-->Bis(pinacolato)diboron-->1-Methylpiperazine

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